Computer science • Genetics • Health • Medicine • Molecular biology • Pharmacy
A number of technologies and tools got a chance to prove themselves for the first time in the context of COVID-19. Three researchers working in gene-based vaccines, wearable diagnostics and drug discovery explain how their work rose to the challenge of the pandemic, and their hopes that each technology is now poised to continue making […]
Inherited or somatic mutations targeting genes which encode essential cell growth regulatory proteins favor the emergence of cancer. Cells carrying these mutations acquire growing and survival advantages that trigger the emergence of the tumor. A large number of tumor-associated mutations, as well as many mutations found in the germline of hereditary cancer patients, are single-nucleotide […]
Gliomas are the most prevalent subtype of primary brain tumours originating from mutations of the glia cells in the central nervous system. Gliomas are characterized by fast cell growth, strong invasion capability, and well-developed tumour vasculature. Although research and clinical trials have allowed significant progress in the comprehension and treatment of gliomas, they still have […]
In March 2020, a multidisciplinary task force (so-called Basque Modelling Task Force, BMTF) was created to assist the Basque health managers and Government during the COVID-19 responses. BMTF works creating a model based on different approaches: stochastic processes, statistical methods and artificial intelligence. The efforts and challenges to develop a flexible modelling framework able to […]
Parkinson’s disease is characterized by neuronal loss in the brain’s substantia nigra region. What if another cell type, namely, astrocytes, could replace them? The work of two research groups recently published Zhou, H. et al. Cell 181, 590–603.e16 (2020). shows that, at least in mice, transforming astrocytes (a non-neuronal cell type in the brain) into […]
Chronic diseases are already having and will continue to have not only profound economic, social and individual consequences but also a major impact on the use of health resources and design of new care processes. Chronic obstructive pulmonary disease (COPD) is a case on point. COPD is airflow limitation caused by an inflammatory response to […]
It seems that the genetic risk of an APOE4 variant in the APOE gene would not only increase risk for Alzheimer’s but also would increase the chances of getting infected by the COVID-19 virus. The APO protein is involved in cholesterol metabolism and the immune system. However, its precise role in Alzheimer’s disease is as […]
Gene therapy was a 90s hit. The most promising medical advance of the decade was almost forgotten after some really serious side effects occurred in one clinical trial, but after nearly 3 decades a small trial in Germany has shown gene therapy not only to be safe for use in humans but also to have […]
Author: Mikel Lezaun is professor at the University of the Basque Country – UPV/EHU where he is director of the Mathematical Technology Transfer Group Production centers for blood components have the job of supplying hospitals with the products that they need in time and strive to discard as few units as possible due to outdating […]
The Hodgkin-Huxley model for the generation of the nerve action potential is one of the most successful mathematical models of a complex biological process that has ever been formulated. Alan Hodgkin and Andrew Huxley described the model in 1952 to explain the ionic mechanisms underlying the initiation and propagation of action potentials in the squid […]