T-cell acute lymphoblastic leukemia (T-ALL) and T-cell acute lymphoblastic lymphoma (T-LBL) are aggressive hematological malignancies that arise from abnormal activation of oncogenes and/or inactivation of tumor-suppressor genes, followed by a differentiation arrest and uncontrolled clonal expansion of immature thymocytes . Proviral integration site for Moloney-murine leukemia 1 (PIM1) is a known JAK-STAT target gene that […]
T-cell lymphoblastic lymphoma (T-LBL) is a precursor T cell lymphoma. T-LBL represents the second most common subtype of Non-Hodgkin lymphoma in both children and adolescents; however, it is less common in adults . T-LBL share many characteristics with the precursor T cell leukemia (T-ALL), however, various studies have indicated that T-ALL and T-LBL might be […]
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a poor prognosis and limited options for targeted therapies . Since the targeted therapies benefiting T-ALL are still limited owing to the biological heterogeneity of T-ALL , identifying novel “druggable” molecular markers and illustrating the underlying mechanisms are immediate pressing issues in T-ALL […]
T-cell acute lymphoblastic leukemia (T-ALL) is characterized by the accumulation of genetic lesions that induce differentiation arrest, survival and aberrant proliferation of immature T-cell progenitors . Although T-ALL prognosis has significantly improved due to intensive chemotherapy, relapses still occur in 20% of pediatric patients and 50% of adult patients, often with a dismal outcome. To […]
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy that affects both children and adults. Although with current chemotherapy regimens cure is achieved in ~80% of pediatric patients, adults fare more poorly with only 40% 5-year overall survival . Restricted cellular subsets with asymmetrically enriched leukemia-initiating cell (LIC) activity have been reported in human and […]
Hypoxia Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Despite the fact that c ancer treatments have greatly improved during recent years, chemoresistance remains a major problem in eradicating cancer cells. Drug resistance involves not only many cell intrinsic mechanisms but also extrinsic induced chemoprotection by the tumor microenvironment . In fact, this […]
Understanding the origin of heavy elements on the periodic table is one of the most challenging open problems in all physics. In the search for conditions suitable for these elements via “nucleosynthesis,” a Los Alamos National Laboratory-led team is going where no researchers have gone before: the gamma-ray burst jet and surrounding cocoon emerging from […]
Whale songs reveal similarities to human speech Two new studies reveal that whale songs share sophisticated similarities with human speech, challenging the uniqueness of human language. Researchers found that humpback whales exhibit communication efficiency akin to human languages, adhering to linguistic laws such as Menzerath’s and Zipf’s laws. Full Story: ScienceAlert Birds, mammals evolved complex […]
T-cell acute lymphoblastic leukemia (T-ALL) is a devastating disease of T-cell progenitors that mainly affects children and young adults. Numerous genomic alterations are known to induce survival, proliferation, and differentiation of T-ALL cells . The interactions between leukemic cells and their microenvironment are known factors that contribute to T-ALL pathogenesis. The bone marrow (BM) microenvironment […]
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that results from transformation and clonal expansion of developmentally-arrested T-cell progenitors . Conventional risk-adjusted multi-agent chemotherapy allows for high 5-year event-free survival rates in children. However, a significant number of patients still relapse or do not respond to therapy. Consequently, there have been considerable efforts […]