Search results: antimicrobial resistance

Combatting antimicrobial resistance with a ruthenium-based photorelease antimicrobial therapy

Combatting antimicrobial resistance with a ruthenium-based photorelease antimicrobial therapy

ChemistryCondensed matterMedicineMicrobiologyPharmacy

By DIPC

Antimicrobial resistance is a complex problem that contributes to health and economic losses worldwide. Resistance to antimicrobial therapies reduces the effectiveness of current drugs, leading to increased morbidity, mortality, and health care expenditure. Because globalization increases the vulnerability of any country to diseases occurring in other countries, resistance presents a major threat to global public […]

Antimicrobial peptides let ions through membranes without boring holes

Antimicrobial peptides let ions through membranes without boring holes

BiochemistryChemistryDIPC PolymersPharmacy

By DIPC

Antimicrobial peptides (AMPs) are highly potent and broad-spectrum antibiotics, found as components of the innate immune system in almost all forms of life. AMPs are short proteins, tiny compared with conventional antibiotics but extraordinarily effective: they bind to and disrupt bacterial membranes, which quickly incapacitates or kills a cell. For decades, the picture many scientists […]

Drug combinations to combat antibiotic resistance

Drug combinations to combat antibiotic resistance

BiologyBiomedicineMedicinePharmacy

By Rosa García-Verdugo

One of the biggest health threats in our current society is not related to a virus, not even to diabetes or cardiovascular disease, but to antimicrobial resistance. In fact, over 5 million deaths per year are associated with resistant bacteria, of which nearly 1.3 million deaths per year are directly attributable to antimicrobial resistance. This […]

Could excipients decrease antimicrobial properties? Citronellal oil and cyclodextrins

Could excipients decrease antimicrobial properties? Citronellal oil and cyclodextrins

Biochemistry

By Invited Researcher

Departamento de Bioquímica y Biología molecular-A, Facultad de Biología, Universidad de Murcia, E-30100 Murcia, Spain * adrian.matencio@um.es Antimicrobial resistance is a problem in our society. Although several authors have focused on seeking new molecules with antimicrobial activity, resistance has increased. Several authors are looking for new antimicrobial substances or seeking to improve the use of […]

Environmental DNA: Biodiversity data (like love) is in the air

Environmental DNA: Biodiversity data (like love) is in the air

BiologyEcologyGenetics

By Invited Researcher

DNA sequencing is getting cheaper than ever. This, coupled with advances in speed and portability, are allowing us to apply deep sequencing beyond the lab to environmental substrates, and analyse this eDNA to gain information and monitor biodiversity at a time where it is being lost at an unprecedented rate. This environmental DNA can be […]

MI weekly selection #470

MI weekly selection #470

Weekly Selection

By César Tomé

AI identifies viruses with high zoonotic potential Artificial intelligence identified viruses in the bunyavirus, rhabdovirus, filovirus and flavivirus families as the viruses most likely to spill over from animals to humans, and the platform may help researchers better estimate risks of zoonosis within viral families. The computer model also identified the Amazon River basin as […]

The rise of the superbugs

The rise of the superbugs

MicrobiologyPharmacy

By Sergio Laínez

Our society will be facing a number of health-related challenges in the near future, partly as a consequence of our own practices. Perhaps the best known examples are the (severe) health issues linked to smoking (not just to smokers, but also their children via epigenetic changes) or the abnormally high intake of carbohydrates, with the […]

MI weekly selection #563

MI weekly selection #563

Weekly Selection

By César Tomé

Seahenge may have been built to combat climate change Seahenge, an ancient timber monument discovered on an English beach, may have been built to counteract climate deterioration, according to a study in GeoJournal. The research suggests that Seahenge and the nearby Holme II were ritual structures aimed at bringing warmth during periods of severe cold […]

Enzybiotics, from phages to the inhaler.

Enzybiotics, from phages to the inhaler.

BiomedicineMedicineMicrobiologyPharmacy

By Invited Researcher

I n the age of bacteria resistant to multiple antibiotics, the so-called superbacteria, it is critical to our future the development of novel therapeutic strategies. Lytic enzymes encoded by bacteriophages – viruses that specifically kill bacteria, also called lysins or enzybiotics, are effective agents for preventing and controlling diseases caused by Gram+ bacteria, including Streptococcus […]