Search results: epigenetic

Inactivation of tumor suppressor genes (TSGs) confers a cellular fitness advantage to human cancer cells, including in acute myeloid leukemia (AML), where it disrupts myeloid differentiation and promotes leukemogenesis. Loss-of-function mutations in TSGs are frequently observed in patients with hematologic malignancies , driving disease progression by blocking differentiation and enhancing self-renewal. Therefore, restoration of tumor […]

The term epigenetics refers to heritable changes in gene expression (active vs. inactive genes) that does not involve changes to the underlying DNA sequence. It results in change in phenotype without a change in genotype. An easily comprehensible example are identical twins: since they develop from a single fertilized egg, they have the same genome […]

Although not the most important among the many different animals studied by Charles Darwin during his amazing journeys on board the Beagle, the little finches from the Galápagos Islands have become one of the most popular representatives of Darwin’s theory of natural selection. They embody the process of speciation forced by environmental conditions, in the […]

Nowadays there are still people that believe in destiny. However the scientific community more and more is bringing light to that subject showing that although the genetic material could program ourselves to suffer some pathologies, the day-to-day experiences are the ones that lead us towards a healthy or pathological aging. And how is that? Our […]

Could your parents’ lifestyle choices affect how long you live? And could this effect not be directly related to your genes? Scientists studying my favourite roundworm (C. elegans) have discovered a surprising answer: yes, they can. Why does the offspring live longer? Researchers at HHMI’s Janelia Research Campus made an unexpected discovery while studying aging […]

Can a father’s lifestyle choices before conception influence the health of his future children? New research reveals that environmental factors affecting fathers can leave molecular footprints in embryos, shaping development and potentially impacting long-term health. Epigenetic inheritance For decades, scientists believed that inheritance was controlled exclusively by DNA sequences passed from parents to offspring. Today […]

Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal expansion of plasma cells in the bone marrow (BM) . Nearly 90% of myeloma patients suffer from skeletal-related events during the course of the disease that not only affect the quality of life but also their overall survival . Myeloma-associated bone disease (MBD) is […]

A predictive tool for determining the age at which individuals may develop mild cognitive impairment (MCI) or Alzheimer’s dementia (AD) has demonstrated the ability to predict MCI onset within 2.78 years and AD onset within 1.48 years. Developed by Florey Institute of Neuroscience and Mental Health researchers, collaborating with the Alzheimer’s Disease Neuroimaging Initiative (ADNI) […]

Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Alzheimer’s disease (AD) is a […]

Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the uncontrolled expansion of the immature myeloid cells . The 5-year survival rates of young patients are 40–50% and less than 15% for patients aged over 60 . For this reason, a great effort has been made to decipher the molecular events underlying AML […]