For decades, Alzheimer’s research has been dominated by a seemingly intuitive idea: the disease is largely explained by the accumulation of abnormal proteins in the brain, primarily beta-amyloid and tau. However, while this view has been useful, it has fallen short in explaining certain fundamental aspects. One of the most striking is that Alzheimer’s affects […]
Chimeric antigen-specific receptor (CAR) T-cell immunotherapy targeting B-cell maturation antigen (BCMA; BCMA-CAR T cells) has produced remarkable clinical responses in advanced multiple myeloma (MM), with a substantial fraction of patients achieving complete remission . However, many patients relapse within months, largely due to insufficient CAR T-cell persistence, a recognized mechanism of acquired resistance . A […]
Phagocytosis Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Phagocytosis of cancer cells by tumor-associated macrophages (TAMs), which are abundant in the tumor microenvironment (TME), plays a critical role in cancer immunosurveillance . Cancer cells can evade macrophage-mediated phagocytosis (the process by which a cell uses its plasma membrane to engulf particles or […]
Human bones in Spanish cave were likely used as tools Ancient humans excavated and modified the skeletons of their buried ancestors to possibly use as tools, according to a study from scientists studying remains at the Cueva de los Marmoles cave in southern Spain. Researchers identified the remains of at least 12 people buried between […]
Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Since COVID-19 disease arrived in our lives at the beginning of last year, we are giving increased importance to our immune system status. We are worried about if it is working properly and can attack correctly the SARS-CoV-2. For this reason, lot of people are […]
The scientific community, in their different fields and specialties, has made tremendous progress regarding human health and how we deal with all the maladies affecting mankind. Particularly in cancer, the Pulitzer Prize-winning book entitled “The Emperor of All Maladies” summarizes in a marvelous way this notion. However, I am convinced that our struggle against cancer […]
Most people in Spain have heard about the ongoing bitter polemic between the Victims of Hepatitis C Platform and the Spanish government with regard to the access to a new medication called Sovaldi approved by the Spanish government last 1st October. The main reason for such clash between them is simple: the asking price for […]