Search results: single-cell

New single-cell tool reveals hidden links between genes and disease

New single-cell tool reveals hidden links between genes and disease

GeneticsMedicine

By Rosa García-Verdugo

Ever wondered why certain diseases seem to run in families, or how tiny changes in our DNA can lead to serious health conditions? Scientists have developed a powerful new tool that simultaneously analyzes both DNA and RNA within individual cells, offering unprecedented insight into how genetic variations contribute to disease. The Problem With Current Technology […]

Single-Cell Barcoding: Another way to understand the behaviour of a cell population

Single-Cell Barcoding: Another way to understand the behaviour of a cell population

BiologyGenetics

By Daniel Moreno Andrés

Since the cells were discovered with the advent of the microscope in the late seventeenth century, scientists have tried hard to find out what is going on into them. An avalanche of techniques and technologies emerged over the course of decades slowly discovering important molecular features of the cellular world to our knowledge and our […]

Classification of sensory neuron types applying single-Cell RNA sequencing

Classification of sensory neuron types applying single-Cell RNA sequencing

BiochemistryGeneticsNeurobiology

By Sergio Laínez

In 1968, the Canadian psychologist from McGill University Ronald Melzack described pain as being multidimensional and complex, with sensory-discriminative, affective-motivational and cognitive-evaluative components . Such definition may be a hint as to why the biological meaning of pain has been an (to date) unceasing matter of debate since Aristotle, who thought pain is just a […]

Inflammation-driven changes in bone marrow: An early indicator of leukemia?

Inflammation-driven changes in bone marrow: An early indicator of leukemia?

Biomedicine

By Rosa García-Verdugo

What if we could stop blood cancers before they even start? New research reveals that chronic inflammation dramatically reshapes the bone marrow environment years before leukemia emerges, potentially offering a window for early intervention. The Hidden Life of the Bone Marrow Every second, your bone marrow produces millions of new blood and immune cells through […]

The giant viruses that orchestrate life in the polar regions

The giant viruses that orchestrate life in the polar regions

BiologyMicrobiology

By Invited Researcher

Authors: Thomas M. Pitot, Chercheur postdoctoral en microbiologie, Université du Québec à Chicoutimi (UQAC) and Catherine Girard, Professeure-Chercheure en microbiologie, Université Laval Viruses play a major role in the functioning of ecosystems. They profoundly influence the dynamics of microbial communities, flow of matter and global biogeochemical cycles. Yet despite their abundance and ecological importance, many […]

Turning malignancy into normalcy: A computational path to cancer cell reversion

Turning malignancy into normalcy: A computational path to cancer cell reversion

Biomedicine

By Invited Researcher

Throughout the relentless struggle against cancer, conventional medicine has largely depended on aggressive methods of elimination—surgical removal, radiation, and chemotherapy—aimed at eradicating malignant cells before they can overwhelm the patient. While these approaches have proven effective in many cases, they often come at a steep cost, damaging healthy tissue and leaving patients vulnerable to recurrence […]

Animal origami: The physics of nature’s folds

Animal origami: The physics of nature’s folds

BiologyMechanical EngineeringPhysics

By Mapping Ignorance

Author: Rohini Subrahmanyam is a PhD biologist turned science journalist. Insects that tuck away wings; a protist with an accordion-like neck — studying these clever creases may inspire foldable structures for drones As the microscopic, tear-shaped Lacrymaria olor swims around hunting for food, it does something remarkable: In a blink, the tiny protist extends its […]

Biomarkers of chemoresistant leukemic cells in human T-ALL

Biomarkers of chemoresistant leukemic cells in human T-ALL

Biomedicine

By Invited Researcher

T-cell acute lymphoblastic leukemia (T-ALL) is characterized by the accumulation of genetic lesions that induce differentiation arrest, survival and aberrant proliferation of immature T-cell progenitors . Although T-ALL prognosis has significantly improved due to intensive chemotherapy, relapses still occur in 20% of pediatric patients and 50% of adult patients, often with a dismal outcome. To […]