Author archives: Invited Researcher

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Outstanding researchers present their work and share their opinions in Mapping Ignorance.

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

Biomedicine

By Invited Researcher

Acute Myeloid Leukemia (AML) is a hematopoietic neoplasm characterized by the proliferation and accumulation of aberrant immature myeloid progenitor cells. AML is associated with poor clinical outcome and high mortality, with an overall five-year survival rate of less than 15-30%. For AML patients, standard therapies often fail to achieve the complete remission, disease relapse is […]

Electron-cyclotron plasma generation and spectrum characterization

Electron-cyclotron plasma generation and spectrum characterization

Physics

By Invited Researcher

Ernest Lawrence was awarded the Nobel Prize in Physics in November 1939 “for the invention and development of the cyclotron and for results obtained with it, especially with regard to artificial radioactive elements”. His invention was based on generating a spiral accelerated trajectory of protons governed by a simple alternating radio frequency voltage together with […]

Antibody-drug conjugates for the treatment of acute myeloid leukemia

Antibody-drug conjugates for the treatment of acute myeloid leukemia

Biomedicine

By Invited Researcher

Acute myeloid leukemia (AML) is the most common acute leukemia in adults and a common pediatric cancer. Most often, AML develops from cells that would turn into white blood cells. AML is divided into different subtypes based on the cell type and maturation stage. Currently, monocytic AML, including acute myelomonocytic leukemia (M4) and acute monocytic […]

Could the largest known proteins be synthesized by the smallest bacteria?

Could the largest known proteins be synthesized by the smallest bacteria?

BiologyMicrobiology

By Invited Researcher

Author: Ramón Muñoz-Chápuli has been Professor of Animal Biology in the University of Málaga until his retirement. He has investigated for forty years in the fields of developmental biology and animal evolution. On October 11th, I published an article on Mapping Ignorance about the microbial dark matter, the vast diversity of microorganisms that cannot be […]

Scientific censorship for a greater good?

Scientific censorship for a greater good?

EpistemologyPhilosophy of sciencePsychologySociology

By Invited Researcher

“Censorship” is not a pleasant word to anyone. Its connotations are almost always negative and, in the first instance, an effort should be made to find circumstances that justify a restriction of information. Even more so in the scientific field, where empirical evidence should prevail over authority, tradition, rhetorical eloquence or social prestige. Science seeks […]

Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL

Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL

Biomedicine

By Invited Researcher

T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy that affects both children and adults. Although with current chemotherapy regimens cure is achieved in ~80% of pediatric patients, adults fare more poorly with only 40% 5-year overall survival . Restricted cellular subsets with asymmetrically enriched leukemia-initiating cell (LIC) activity have been reported in human and […]