Category Archives: Pharmacy

Lipinski’s “rule of five”,1 very well known by medicinal chemists, has been defined as a set of rules, based on the number 5 -hence its name-, to evaluate the “drug-likeness” of a given molecule. The rules are:
– The […]

Our society will be facing a number of health-related challenges in the near future, partly as a consequence of our own practices. Perhaps the best known examples are the (severe) health issues linked to smoking (not just to smokers, […]

When we hear somebody wheezing, coughing, showing chest tightness and shortness of breath, most of us will immediately recognize the underlying cause: Asthma. This is not a minor issue, but one affecting approximately 5% of the entire world population […]

The immune system is a complex network that recognises foreign substances in the body. When it detects an alien substance (antigen), it creates antibodies to attack and destroy it. This system protects vertebrates against viruses, bacteria, fungi and […]

A recurrent problem with pain is the absence of therapeutic strategies to selectively block the nociceptors (neurons responsible to detect painful stimuli) that need to be targeted for a particular indication. Things get even worse if we take into account […]

There are plenty of examples of drugs that have been repurposed in recent years. For instance, thalidomide, the initially prescribed medication for headache in pregnant women which led to countless numbers of babies born with body malformations during the […]

The combination of catalysis and bioorthogonality promises have an impact on drug discovery and bioimaging. Bioorthogonality, a term coined by Carolyn R. Bertozzi in 2003, refers to any chemical reaction that can occur inside of living systems without interfering with […]

Antimicrobial resistance is a complex problem that contributes to health and economic losses worldwide. Resistance to antimicrobial therapies reduces the effectiveness of current drugs, leading to increased morbidity, mortality, and health care expenditure. Because globalization increases the vulnerability of any […]

15% of human cancers worldwide may be attributed to viruses,1 with both DNA and RNA viruses being capable of causing the disease. Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA […]

Patients suffering from rare diseases (defined by the European as those affecting less than 5 in 10000 people) have traditionally been overlooked by pharmaceutical companies. They are usually looking for the next blockbuster drug, so the lack of a large […]