Chimeric antigen-specific receptor (CAR) T-cell immunotherapy targeting B-cell maturation antigen (BCMA; BCMA-CAR T cells) has produced remarkable clinical responses in advanced multiple myeloma (MM), with a substantial fraction of patients achieving complete remission . However, many patients relapse within months, largely due to insufficient CAR T-cell persistence, a recognized mechanism of acquired resistance . A […]
Artificial intelligence is increasingly being used to solve the mathematical equations that describe the physical world, not only to recognize images or generate text. One promising approach, developed over the last decade, is the physics-informed neural network, or PINN: a type of neural network trained not on labeled examples but on the governing equations of […]
A few weeks after the invasion of Ukraine by the Russian army, many scientific institutions felt the need to issue public statements against that war. At the time, I was president of the Commission for the History of Physics within the International Union of Pure and Applied Physics (IUPAP) and, as such, I took part […]
One of the great unanswered questions in physics concerns the nature of neutrinos, the lightest known particles with mass. A process called neutrinoless double beta decay could provide the answer. In ordinary double beta decay, two neutrons inside a nucleus transform into two protons, emitting two electrons and two antineutrinos. In the neutrinoless version, only […]
For millennia, farming in Switzerland did not reduce plant diversity but helped increase it, researchers have shown in a detailed reconstruction covering the past 7000 years. Only recent decades paint a different picture. The fall of the Roman Empire and major plague outbreaks: These events not only affected people but also reduced plant diversity on […]
Authors: Sergi Muria Maldonado, Professor de Didàctica de les Matemàtiques, Universitat de Barcelona; Anton Aubanell Pou, Professor de l’Institut de Formació Continuada i professor jubilat de Didàctica de les Matemàtiques, Universitat de Barcelona, and Jordi Font González, Professor de Didàctica de les Matemàtiques, Universitat de Barcelona 2026 marks 100 years since the death of Antoni […]
When energy storage is discussed in the context of the energy transition, the conversation almost invariably turns to electricity. Solar and wind power have made the temporal mismatch between energy production and energy demand one of the defining challenges of low-carbon energy systems, and technologies capable of storing electrical energy have consequently become central to […]
When astronomers in the eighteenth century first turned powerful telescopes toward the Milky Way, they noticed something puzzling: tight, spherical swarms of stars scattered across the sky. Now we know that each contains hundreds of thousands of suns packed into a region just a few dozen light-years across. These objects, known today as globular clusters […]
Author: Chris Kirkland, Professor of Geochronology, Curtin University In the Pilbara of Western Australia, some of Earth’s oldest rocks lie beneath the sky, as they have for billions of years. They are dark, weathered volcanic rocks, close to 3.5 billion years old, cut by veins and stewed by deep time. Their survival is remarkable. Most […]
Author: José Luis Granados Mateo is a postdoctoral researcher in the Department of Philosophy at the University of the Basque Country (EHU) and a member of the Integrated History and Philosophy of Science (iHPS) research group. His work focuses on history and philosophy of science, science and values, and the epistemology of scientific practices. A […]