Category archives: Genetics

Multiple Denisovan interbreeding events with modern humans

Multiple Denisovan interbreeding events with modern humans

AnthropologyEvolutionGenetics

By Mapping Ignorance

Scientists believe individuals of the most recently discovered hominin group (the Denisovans) that interbred with modern day humans passed on some of their genes via multiple, distinct interbreeding events that helped shape early human history. In 2010, the first draft of the Neanderthal genome was published, and comparisons with modern human genomes revealed that Neanderthal […]

Iberian lynx’s potential secret weapon against extinction

Iberian lynx’s potential secret weapon against extinction

BiologyGenetics

By Invited Researcher

Many large mammals have lost genetic diversity, often thanks to the actions of people shrinking their populations. The implications can be severe because without genetic diversity, a population does not have a “genetic database” to fall back on to adapt to environmental change. The Iberian lynx (Lynx pardinus) is no stranger to this reduction in […]

The largest animal genome

The largest animal genome

BiologyGenetics

By Invited Researcher

Author: Ramón Muñoz-Chápuli has been Professor of Animal Biology in the University of Málaga until his retirement. He has investigated for forty years in the fields of developmental biology and animal evolution. Lungfish (Dipnoi) are fascinating animals. Despite having gills, they can breathe atmospheric air thanks to a pair of lungs. Their geographic distribution aligns […]

AINU, a powerful AI tool for studying cell heterogeneity

AINU, a powerful AI tool for studying cell heterogeneity

BiologyComputer scienceDIPC SupercomputingGenetics

By DIPC

Chromatin is a complex of DNA and histone, a protein, in the nucleus of a cell. One of the main functions of chromatin is to help DNA packing. Cellular phenotypic heterogeneity is a key determinant of many biological functions; yet, it is still not clear whether it stems from the modifications of the chromatin structure […]

Aborted clinical trials: what genetics has to say

Aborted clinical trials: what genetics has to say

GeneticsMedicinePharmacy

By Rosa García-Verdugo

Many (if not most) clinical trials end up failing, but given the bias towards positive results sometimes the reasons for their not working remain unclear. Luckily, a team at Open Targets and EMBL’s European Bioinformatics Institute (EMBL-EBI) have analysed the reasons for aborted clinical trials mentioned in Clinicaltrials.gov, the open-source register for clinical trials worldwide […]

The final stage in the formation of a ‘European genome’

The final stage in the formation of a ‘European genome’

AnthropologyGenetics

By Invited Researcher

Authors: Eva-Maria Geigl, Directrice de recherche CNRS, co-responsable de l’équipe Épigénome et paléogénome de l’Institut Jacques Monod, Université Paris Cité; Oğuzhan Parasayan, Chercheur post-doctoral, Institut Pasteur, and Thierry Grange, Directeur de Recherche CNRS, co-responsable d’équipe de recherche, Institut Jacques Monod, Université Paris Cité High-resolution analysis of the genomes of individuals buried in a 4,500-year-old collective […]