Numerous proteins in the cell withstand mechanical loads while performing their function. This is especially significant for cell-surface proteins located in the extracellular matrix, which are essential for the communication between cells in the extracellular milieu. Reacting to mechanical force through conformational changes is crucial for these cell-surface proteins, translating a physical signal into an […]
Author: Marc Zimmer, Professor of Chemistry, Connecticut College The 2024 Nobel Prize in chemistry recognized Demis Hassabis, John Jumper and David Baker for using machine learning to tackle one of biology’s biggest challenges: predicting the 3D shape of proteins and designing them from scratch. This year’s award stood out because it honored research that originated […]
The protein “MIPS” changes its internal structure when it becomes active. Its disordered active centre becomes a defined structure with special functions. The protein plays a key role in the production of inositol, which is also known as vitamin B8, and fulfils important tasks in the body. A team of researchers has succeeded for the […]
A new imaging technique can give scientists a much closer look at fibril assemblies, stacks of peptides like amyloid beta, most notably associated with Alzheimer’s disease. These cross-β fibril assemblies are also useful building blocks within designer biomaterials for medical applications, but their resemblance to their amyloid beta cousins, whose tangles are a symptom of […]
Biochemistry • Biomedicine • Health • Medicine • Neuroscience
Recent research has demonstrated that obesity impairs the mechanisms that allow our brains to realize when our stomachs are full and that these changes are maintained despite dieting, giving insights into why it is difficult for obese people to avoid excessive eating and why there is often a yo-yo effect after dieting. It has been […]
Pyrite, also known as “fool’s gold,” is an abundant iron sulphide mineral in the Earth’s crust. All organisms need iron and sulphur to grow. Because pyrite does not dissolve in oxygen-free conditions, scientists previously thought that organisms could not use pyrite in the absence of oxygen. Research shows that certain single-celled microorganisms can dissolve pyrite […]
Plants that inhabit the Earth have the incredible ability to grow continually for hundreds of years, and always towards the light of the sun, which provides them with the necessary energy to sprout. At the source of this growth are changes in their environment, such as variations in light, temperature and humidity. But new stimuli […]
Body odor is present in all mammals, including of course humans. It has a clear genetic basis, although it is modulated by different conditions, both normal and pathological. Interestingly, although it is believed to have an important communicative function and to be involved in sexual attraction, body odor is considered unpleasant by most people, which […]
Dip. Di Chemica, Università di Torino, via P. Giuria 7, 10125, Torino, Italy * adrian.matencioduran@unito.it The last articles of one of us (Matencio) [1,2,3,4] were about the different uses of a complexing agent called cyclodextrin (CD), a torus-shaped oligosaccharide made up of α-(1,4) linked glucose units, the most common CDs being α, β and γ-CD […]
On our unique planet, life evolved under the pressure of natural selection. The evolution theory of Darwin demonstrates the incredible plasticity of the living organism. For millions of years, living organisms explored the conformational universe of proteins introducing new structures and function through genetic mutations. The genetic modifications are translated into the sequence of amino-acids […]