Category archives: Biochemistry

Smelling armpits

Smelling armpits

BiochemistryNeurobiology

By José Ramón Alonso

Body odor is present in all mammals, including of course humans. It has a clear genetic basis, although it is modulated by different conditions, both normal and pathological. Interestingly, although it is believed to have an important communicative function and to be involved in sexual attraction, body odor is considered unpleasant by most people, which […]

Cyclodextrin-based nanosponges as a complexating agent: application in oxyresveratrol complexes

Cyclodextrin-based nanosponges as a complexating agent: application in oxyresveratrol complexes

Biochemistry

By Invited Researcher

Dip. Di Chemica, Università di Torino, via P. Giuria 7, 10125, Torino, Italy * adrian.matencioduran@unito.it The last articles of one of us (Matencio) [1,2,3,4] were about the different uses of a complexing agent called cyclodextrin (CD), a torus-shaped oligosaccharide made up of α-(1,4) linked glucose units, the most common CDs being α, β and γ-CD […]

A universal theory for heteropolymer design

A universal theory for heteropolymer design

BiochemistryChemistryMaterials

By Invited Researcher

On our unique planet, life evolved under the pressure of natural selection. The evolution theory of Darwin demonstrates the incredible plasticity of the living organism. For millions of years, living organisms explored the conformational universe of proteins introducing new structures and function through genetic mutations. The genetic modifications are translated into the sequence of amino-acids […]

Could excipients decrease antimicrobial properties? Citronellal oil and cyclodextrins

Could excipients decrease antimicrobial properties? Citronellal oil and cyclodextrins

Biochemistry

By Invited Researcher

Departamento de Bioquímica y Biología molecular-A, Facultad de Biología, Universidad de Murcia, E-30100 Murcia, Spain * adrian.matencio@um.es Antimicrobial resistance is a problem in our society. Although several authors have focused on seeking new molecules with antimicrobial activity, resistance has increased. Several authors are looking for new antimicrobial substances or seeking to improve the use of […]

Design of protein-protein binding sites suggests a rationale for naturally occurring contact areas

Design of protein-protein binding sites suggests a rationale for naturally occurring contact areas

BiochemistryChemistryMaterials

By Invited Researcher

Molecular recognition is a critical process for many biological functions and consists in non-covalent binding of different molecules, such as protein-protein, antigen-antibody and many others. The host-guest molecules involved often show a shape complementarity, and one of the leading specification for molecular recognition is that the interaction must be selective, i.e. the host should strongly […]

A generalized approach for NMR studies of lipid–protein interactions

A generalized approach for NMR studies of lipid–protein interactions

BiochemistryChemistryMolecular biology

By Invited Researcher

Author: Francisco J. Blanco is an Ikerbasque Research Professor at CIC bioGUNE Molecular interactions in cell membranes, particularly lipid-protein interactions in their hydrophobic core, are difficult to analyse and remain poorly characterised despite high relevance in physiological and pathological processes. Structural rearrangements in membranes and embedded proteins, and the way molecular interactions contribute to their […]

The mechanochemistry of E. coli type 1 pilus

The mechanochemistry of E. coli type 1 pilus

BiochemistryBiomedicineMicrobiology

By DIPC

Uropathogenic Escherichia coli (UPEC) is responsible for approximately 90% of urinary tract infections (UTI) seen in individuals with an ordinary anatomy. In ascending infections, fecal bacteria colonize the urethra and spread up the urinary tract to the bladder as well as to the kidneys (causing pyelonephritis), o or the prostate in males. Because women have […]