Category archives: Biomedicine

Antibody-drug conjugates for the treatment of acute myeloid leukemia

Antibody-drug conjugates for the treatment of acute myeloid leukemia

Biomedicine

By Invited Researcher

Acute myeloid leukemia (AML) is the most common acute leukemia in adults and a common pediatric cancer. Most often, AML develops from cells that would turn into white blood cells. AML is divided into different subtypes based on the cell type and maturation stage. Currently, monocytic AML, including acute myelomonocytic leukemia (M4) and acute monocytic […]

Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL

Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL

Biomedicine

By Invited Researcher

T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy that affects both children and adults. Although with current chemotherapy regimens cure is achieved in ~80% of pediatric patients, adults fare more poorly with only 40% 5-year overall survival . Restricted cellular subsets with asymmetrically enriched leukemia-initiating cell (LIC) activity have been reported in human and […]

Drug combinations to combat antibiotic resistance

Drug combinations to combat antibiotic resistance

BiologyBiomedicineMedicinePharmacy

By Rosa García-Verdugo

One of the biggest health threats in our current society is not related to a virus, not even to diabetes or cardiovascular disease, but to antimicrobial resistance. In fact, over 5 million deaths per year are associated with resistant bacteria, of which nearly 1.3 million deaths per year are directly attributable to antimicrobial resistance. This […]

p21 is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia

p21 is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia

Biomedicine

By Invited Researcher

Phagocytosis Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Phagocytosis of cancer cells by tumor-associated macrophages (TAMs), which are abundant in the tumor microenvironment (TME), plays a critical role in cancer immunosurveillance . Cancer cells can evade macrophage-mediated phagocytosis (the process by which a cell uses its plasma membrane to engulf particles or […]

Precise cell division and cognition in modern humans

Precise cell division and cognition in modern humans

BiologyBiomedicineGeneticsMolecular biology

By Daniel Moreno Andrés

Cell division, or mitosis, is a breathtaking choreography that showcases the grandeur of life. The primary objective of this process is to meticulously separate the two copies of the cell genome, presented in the form of chromatin, and allocate them between two daughter cells. Consequently, it holds paramount significance for the reproduction of unicellular organisms […]

Platelets participate in hippocampal neurogenesis and cognitive function

Platelets participate in hippocampal neurogenesis and cognitive function

BiologyBiomedicineNeurobiology

By Invited Researcher

Platelets Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. There is currently a […]