Acute B-cell progenitor acute lymphoblastic leukemia (B-ALL) is a clonal hematopoietic neoplasm characterized by the proliferation and accumulation of B-lymphoid progenitor cells throughout the bone marrow. Although important studies have characterized the underlying biological pathways that underpin therapy failure , resistance and subsequent relapse remain a leading cause of cancer-related deaths . One approach to […]
The human oral microbiota is highly diverse and has a complex ecology, including numerous species and strains of bacteria, microeukaryotes, archaea and viruses. This oral microbiome interfaces with the immune system of the human host and has an important role in not only the health of the oral cavity, but in the health of the […]
Amniotic fluid contains cells, cells shed by the growing fetus and which could be used to build “mini organs” in vitro, as a new study reports . What do we mean by “mini organs”? This so-called organoids are 3D cellular systems that aim to replicate the structure and function of real organs but at a […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently, he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Senescence can be defined as […]
Acute Myeloid Leukemia (AML) is a hematopoietic neoplasm characterized by the proliferation and accumulation of aberrant immature myeloid progenitor cells. AML is associated with poor clinical outcome and high mortality, with an overall five-year survival rate of less than 15-30%. For AML patients, standard therapies often fail to achieve the complete remission, disease relapse is […]
Acute myeloid leukemia (AML) is the most common acute leukemia in adults and a common pediatric cancer. Most often, AML develops from cells that would turn into white blood cells. AML is divided into different subtypes based on the cell type and maturation stage. Currently, monocytic AML, including acute myelomonocytic leukemia (M4) and acute monocytic […]
Source: Zhang et al. (2023) Despite their importance in our daily lives, we do not give much importance to our hands or feet, and even less at how they came to be. Even if roughly known, the process of human limb development had never been observed at single cell level resolution. Recently, Sarah Teichmann and […]
To eat, a cell needs to carry its main nutrients (sugars, lipids, and peptides –pieces of proteins–) across the cell membrane. To do so, it has a number of molecular transporters. Interestingly, although sugar transporters are highly specific to the type of sugar they transport, peptide transporters are not picky at all. This promiscuity has […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Solid cancerous tumor is a […]
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy that affects both children and adults. Although with current chemotherapy regimens cure is achieved in ~80% of pediatric patients, adults fare more poorly with only 40% 5-year overall survival . Restricted cellular subsets with asymmetrically enriched leukemia-initiating cell (LIC) activity have been reported in human and […]