T-cell acute lymphoblastic leukemia (T-ALL) is a devastating disease of T-cell progenitors that mainly affects children and young adults. Numerous genomic alterations are known to induce survival, proliferation, and differentiation of T-ALL cells . The interactions between leukemic cells and their microenvironment are known factors that contribute to T-ALL pathogenesis. The bone marrow (BM) microenvironment […]
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that results from transformation and clonal expansion of developmentally-arrested T-cell progenitors . Conventional risk-adjusted multi-agent chemotherapy allows for high 5-year event-free survival rates in children. However, a significant number of patients still relapse or do not respond to therapy. Consequently, there have been considerable efforts […]
Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the uncontrolled expansion of the immature myeloid cells . The 5-year survival rates of young patients are 40–50% and less than 15% for patients aged over 60 . For this reason, a great effort has been made to decipher the molecular events underlying AML […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. There is strong evidence that […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. The research group of Wang […]
Acute myeloid leukemia (AML) is a stem cell disease caused by the massive mobilization and differentiation arrest in primordial granulocytes. AML is characterized by a low survival rate and high recurrence . Although differentiation-induction therapy represents an innovative treatment strategy for AML , many problems still exist, including irreversible resistance, toxic effects, and limitations of […]
Acute B-cell progenitor acute lymphoblastic leukemia (B-ALL) is a clonal hematopoietic neoplasm characterized by the proliferation and accumulation of B-lymphoid progenitor cells throughout the bone marrow. Although important studies have characterized the underlying biological pathways that underpin therapy failure , resistance and subsequent relapse remain a leading cause of cancer-related deaths . One approach to […]
The human oral microbiota is highly diverse and has a complex ecology, including numerous species and strains of bacteria, microeukaryotes, archaea and viruses. This oral microbiome interfaces with the immune system of the human host and has an important role in not only the health of the oral cavity, but in the health of the […]
Amniotic fluid contains cells, cells shed by the growing fetus and which could be used to build “mini organs” in vitro, as a new study reports . What do we mean by “mini organs”? This so-called organoids are 3D cellular systems that aim to replicate the structure and function of real organs but at a […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently, he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Senescence can be defined as […]