For decades, biology textbooks have repeated the same idea with almost ritual certainty: neural stem cells, the cells that fuel the birth of neurons and glia during development, live exclusively inside the brain and spinal cord. They are the architects of the central nervous system, and nowhere else. It has always seemed like an elegant […]
T-cell acute lymphoblastic leukemia (T-ALL) and T-cell acute lymphoblastic lymphoma (T-LBL) are aggressive hematological malignancies that arise from abnormal activation of oncogenes and/or inactivation of tumor-suppressor genes, followed by a differentiation arrest and uncontrolled clonal expansion of immature thymocytes . Proviral integration site for Moloney-murine leukemia 1 (PIM1) is a known JAK-STAT target gene that […]
T-cell lymphoblastic lymphoma (T-LBL) is a precursor T cell lymphoma. T-LBL represents the second most common subtype of Non-Hodgkin lymphoma in both children and adolescents; however, it is less common in adults . T-LBL share many characteristics with the precursor T cell leukemia (T-ALL), however, various studies have indicated that T-ALL and T-LBL might be […]
During the last decade, neurodegenerative diseases have often been described as fires spreading silently from one neuron to another. We knew that misfolded proteins such as alpha‑synuclein could travel across neural circuits, igniting new pathological hotspots along the way. What we did not know is that, behind the scenes, astrocytes —those tireless caretakers of the […]
Have you ever wondered how your ears can pick up the faintest whisper yet also handle loud music without damage? Scientists at Rockefeller University have achieved a remarkable feat : they kept a tiny piece of cochlea alive and working outside the body, allowing them to witness the hearing process in unprecedented detail. Building a […]
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a poor prognosis and limited options for targeted therapies . Since the targeted therapies benefiting T-ALL are still limited owing to the biological heterogeneity of T-ALL , identifying novel “druggable” molecular markers and illustrating the underlying mechanisms are immediate pressing issues in T-ALL […]
Throughout the relentless struggle against cancer, conventional medicine has largely depended on aggressive methods of elimination—surgical removal, radiation, and chemotherapy—aimed at eradicating malignant cells before they can overwhelm the patient. While these approaches have proven effective in many cases, they often come at a steep cost, damaging healthy tissue and leaving patients vulnerable to recurrence […]
Acute myeloid leukemia (AML) with t(6;9)/DEK::NUP214 is recognized as a separate entity in the World Health Organization classification of myeloid neoplasms, accounting for 1% of all AML cases and characterized by a high relapse rate and young age at diagnosis . The t(6;9) chromosomal rearrangement results in the fusion of almost the entire peptide sequence […]
Authors: Gráinne Tyrrell, Doctoral Researcher in Biomedical Device Design, School of Architecture and Product Design, University of Limerick; Eoin White, Associate Professor of Medtech Design, University of Limerick, and Leonard O Sullivan, Professor in Ergonomics and Human Factors, Department of Science and Engineering, University of Limerick “If you can’t handle this, you’ll never keep up […]
T-cell acute lymphoblastic leukemia (T-ALL) is characterized by the accumulation of genetic lesions that induce differentiation arrest, survival and aberrant proliferation of immature T-cell progenitors . Although T-ALL prognosis has significantly improved due to intensive chemotherapy, relapses still occur in 20% of pediatric patients and 50% of adult patients, often with a dismal outcome. To […]