Category archives: Biomedicine

Dr. Jekyll and Mr. Hyde: what changes in a stem cell to become malignant?

Dr. Jekyll and Mr. Hyde: what changes in a stem cell to become malignant?

Biomedicine

By Invited Researcher

Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Research in oncology advances very […]

STOP the STOP in cancer: evading pathogenic premature translation termination of tumor suppressors

STOP the STOP in cancer: evading pathogenic premature translation termination of tumor suppressors

BiomedicineMedicineMolecular biology

By Invited Researcher

Inherited or somatic mutations targeting genes which encode essential cell growth regulatory proteins favor the emergence of cancer. Cells carrying these mutations acquire growing and survival advantages that trigger the emergence of the tumor. A large number of tumor-associated mutations, as well as many mutations found in the germline of hereditary cancer patients, are single-nucleotide […]

Multiscale mathematical models for glioma progression

Multiscale mathematical models for glioma progression

BiomedicineMathematicsMedicine

By BCAM

Gliomas are the most prevalent subtype of primary brain tumours originating from mutations of the glia cells in the central nervous system. Gliomas are characterized by fast cell growth, strong invasion capability, and well-developed tumour vasculature. Although research and clinical trials have allowed significant progress in the comprehension and treatment of gliomas, they still have […]

Is the intranasal route a “backdoor” used by SARS-CoV-2 to reach the brain fortress?

Is the intranasal route a “backdoor” used by SARS-CoV-2 to reach the brain fortress?

BiomedicineNeurobiology

By Invited Researcher

The intranasal route is a rapid, efficient and direct way for different biological agents, small molecules, drugs and chemical compounds to reach the brain. It seems amazing, but people that snort a line of coke already knew that… To date, its mechanism of diffusion is believed to be using either olfactory nerve tracts or dense […]

Genetic risk for Alzheimer’s also predisposes for COVID-19 infection

Genetic risk for Alzheimer’s also predisposes for COVID-19 infection

BiomedicineGeneticsMedicine

By Rosa García-Verdugo

It seems that the genetic risk of an APOE4 variant in the APOE gene would not only increase risk for Alzheimer’s but also would increase the chances of getting infected by the COVID-19 virus. The APO protein is involved in cholesterol metabolism and the immune system. However, its precise role in Alzheimer’s disease is as […]

Could regulators of the immune system have a role in schizophrenia?

Could regulators of the immune system have a role in schizophrenia?

BiomedicineNeurobiology

By Invited Researcher

In a new publication led by Dr. Albert Giralt, the researchers discovered the interaction between a transcription factor identified as “Helios” and a protein called “WDFY1” that could help elucidate the link between immunity and schizophrenia . Schizophrenia is an incurable mental illness characterized by relapsing episodes of psychosis. This disorder affects approximately 1% of […]