
PIM1 Activation in T-ALL: A Therapeutic Vulnerability
T-cell acute lymphoblastic leukemia (T-ALL) and T-cell acute lymphoblastic lymphoma (T-LBL) are aggressive hematological malignancies that arise from abnormal activation of oncogenes and/or inactivation of tumor-suppressor genes, followed by a differentiation arrest and uncontrolled clonal expansion of immature thymocytes . Proviral integration site for Moloney-murine leukemia 1 (PIM1) is a known JAK-STAT target gene that […]








