
DEK::NUP214 acts as an XPO1-dependent transcriptional activator of essential leukemia genes
Acute myeloid leukemia (AML) with t(6;9)/DEK::NUP214 is recognized as a separate entity in the World Health Organization classification of myeloid neoplasms, accounting for 1% of all AML cases and characterized by a high relapse rate and young age at diagnosis . The t(6;9) chromosomal rearrangement results in the fusion of almost the entire peptide sequence […]








