Author archives: Invited Researcher

Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL

Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-ALL

Biomedicine

By Invited Researcher

T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy that affects both children and adults. Although with current chemotherapy regimens cure is achieved in ~80% of pediatric patients, adults fare more poorly with only 40% 5-year overall survival . Restricted cellular subsets with asymmetrically enriched leukemia-initiating cell (LIC) activity have been reported in human and […]

p21 is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia

p21 is a target for phagocytosis-mediated cellular immunotherapy in acute leukemia

Biomedicine

By Invited Researcher

Phagocytosis Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Phagocytosis of cancer cells by tumor-associated macrophages (TAMs), which are abundant in the tumor microenvironment (TME), plays a critical role in cancer immunosurveillance . Cancer cells can evade macrophage-mediated phagocytosis (the process by which a cell uses its plasma membrane to engulf particles or […]

Is new physics needed to explain the early galaxy problem?

Is new physics needed to explain the early galaxy problem?

AstronomyAstrophysicsCosmology

By Invited Researcher

early galaxy problem Author: Rajendra Gupta, Adjunct professor, Physics, L’Université d’Ottawa/University of Ottawa Early universe observations by the James Webb Space Telescope (JWST) cannot be explained by current cosmological models. These models estimate the universe to be 13.8 billion years in age, based on the big-bang expanding universe concept. My research proposes a model that […]

Platelets participate in hippocampal neurogenesis and cognitive function

Platelets participate in hippocampal neurogenesis and cognitive function

BiologyBiomedicineNeurobiology

By Invited Researcher

Platelets Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. There is currently a […]

Cutaneous lymphocyte antigen is a potential therapeutic target in cutaneous T-cell lymphoma

Cutaneous lymphocyte antigen is a potential therapeutic target in cutaneous T-cell lymphoma

Biomedicine

By Invited Researcher

Cutaneous Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Cutaneous T-cell lymphoma (CTCL) is a rare type of cancer that begins in white blood cells called T cells (T lymphocytes). These cells normally help the body’s immune system to fight germs and pathogens. In cutaneous T-cell lymphoma, T cells acquire aberrant functions that […]

The afterglow of an explosive collision between giant planets in a star system far away

The afterglow of an explosive collision between giant planets in a star system far away

Astronomy

By Invited Researcher

collision Authors: Simon Lock, NERC Research Fellow, School of Earth Sciences, University of Bristol; Matthew Kenworthy, Associate professor in Astronomy, Leiden University, and Zoe Leinhardt, Associate Professor, School of Physics, University of Bristol The afterglow of a massive collision between two giant planets may have been detected for the first time. The wreckage of the […]