One of the hallmarks of aging is cognitive decline. New research in mice shows that long-term administration with tetrahydrocannabinol (THC), the primary psicoactive component of marihuana, at low doses can have antiaging-effects, particularly on cognitive decline. The endocannabinoid system (ECS) regulates various bodily and brain functions, including sleep, memory and learning, the immune system and […]
Many (if not most) clinical trials end up failing, but given the bias towards positive results sometimes the reasons for their not working remain unclear. Luckily, a team at Open Targets and EMBL’s European Bioinformatics Institute (EMBL-EBI) have analysed the reasons for aborted clinical trials mentioned in Clinicaltrials.gov, the open-source register for clinical trials worldwide […]
Our DNA is a puzzle resulting from millions of years of evolution. An ancient part of it is composed of the genetic material of viruses that integrated in our genome and became part of “us.” Though it may seem strange, about 7% of our genomes are comprised by these old viral sequences. What’s more, recent […]
Pain is highly personal. What to some doesn’t even deserve the name, for others can be unbereable. Now, we just discovered a difference in how we feel it: men and women have different pain receptors. Recent research has demonstrated in rodents and, importantly, primates including humans, that there are sex differences in pain receptors, also […]
One of the things I mostly hated in school was having to practise my calligraphy skills, I found it monotonous and uninspiring. However, despite not having served to improve my handwriting, it may have helped me fixate new information during my studies, as new research points towards handwriting being better than typing for learning and […]
Amniotic fluid contains cells, cells shed by the growing fetus and which could be used to build “mini organs” in vitro, as a new study reports . What do we mean by “mini organs”? This so-called organoids are 3D cellular systems that aim to replicate the structure and function of real organs but at a […]
Roundworms are the most commonly used animal model to investigate aging and methods to increase the lifespan such as intermittent fasting. Latest research indicates that jumping genes could be another target for interventions aiming towards expanding the lifespan. What are jumping genes? Also called transposons, are movable stretches of DNA of possible viral origin that […]
Source: Zhang et al. (2023) Despite their importance in our daily lives, we do not give much importance to our hands or feet, and even less at how they came to be. Even if roughly known, the process of human limb development had never been observed at single cell level resolution. Recently, Sarah Teichmann and […]
To eat, a cell needs to carry its main nutrients (sugars, lipids, and peptides –pieces of proteins–) across the cell membrane. To do so, it has a number of molecular transporters. Interestingly, although sugar transporters are highly specific to the type of sugar they transport, peptide transporters are not picky at all. This promiscuity has […]
Biology • Biomedicine • Medicine • Pharmacy
One of the biggest health threats in our current society is not related to a virus, not even to diabetes or cardiovascular disease, but to antimicrobial resistance. In fact, over 5 million deaths per year are associated with resistant bacteria, of which nearly 1.3 million deaths per year are directly attributable to antimicrobial resistance. This […]