Amyloid plaques are a hallmark of some neurodegenerative diseases like Alzheimer’s or Parkinson’s. Even though the exact role of amyloid protein in the disease is not clear, being able to follow amyloid protein misfolding and plaque formation could be a step forward for the study of the disease. Now, Matthew Lew’s lab has developed a […]
The brain could be said to be an ubiquitous organ. So much so, that in the heart there is what is called the intracardiac nervous system. Now, a team of researchers at Thomas Jefferson University in Philadelphia has created a 3D image of this heart’s brain in rats. So far that was not possible because […]
It seems that the genetic risk of an APOE4 variant in the APOE gene would not only increase risk for Alzheimer’s but also would increase the chances of getting infected by the COVID-19 virus. The APO protein is involved in cholesterol metabolism and the immune system. However, its precise role in Alzheimer’s disease is as […]
Stem cells were the pioneering force behind the new wave of personalized medicine of the last decade, while CRISPR and other gene-editing techniques have come to revolutionize gene therapy and the treatment of genetic diseases. It had to happen that they would eventually join forces. A new study has used gene-edited stem cells to revert […]
Gene therapy was a 90s hit. The most promising medical advance of the decade was almost forgotten after some really serious side effects occurred in one clinical trial, but after nearly 3 decades a small trial in Germany has shown gene therapy not only to be safe for use in humans but also to have […]
For a long time it has been posed that induced pluripotent stem cells or iPSC have a great potential in the treatment of certain health issues, what’s more, attending to the results of a recently published study in the journal PNAS , iPSC can be helpful to revert brain stroke damage in mice. Sara Palma-Tortosa […]
Humans are not the only animals with a taste for alcohol. It has been described in different animals in the wild, especially mammals, that they do like to eat overripe fermented fruit, and with it experience similar effects to the ones almost all of us are familiar with. It turns out that some mammals cannot […]
A reported case study in a Colombian woman , member of a family carriers of a mutation in the presinilin 1 gene which leads to early onset Alzheimer’s, has shown that a certain mutation in the gene APOE3 can protect from the cognitive decline associated with Alzheimer’s disease. This woman was already aged 70 but […]
As important as remembering, it is forgetting. As Sherlock Holmes said the brain is like a room that you furnish with memories but where space is limited and unnecesary information should be erased. Much on how this erasing works is unkown, but a new study points out to a certain immune cell population in the […]
Too much of anything is usually a mistake, when we speak of a substance of abuse so common, and so easy to find as alcohol we can really get in trouble. Why do some indulge in too much drinking while others seem to easily control those urges is a valid question for which there is […]