Category archives: Genetics

About lefties and righties

About lefties and righties

GeneticsNeuroscience

By Daniel Moreno Andrés

Behind the symmetrical shell of humans and vertebrates lies a profound asymmetry. Our bilaterality breaks down inside our body. Not only our viscera are organized asymmetrically. Also our brain and nervous system, whose general appearance seems symmetrical, present lateralized structure and functioning. Among cognitive systems for example, language, attention, emotional processing, working memory and executive […]

Melodrama with happy ending for Duchenne Muscular Dystrophy patients

Melodrama with happy ending for Duchenne Muscular Dystrophy patients

BiologyBiomedicineGeneticsMedicinePharmacy

By Sergio Laínez

Patients suffering from rare diseases (defined by the European as those affecting less than 5 in 10000 people) have traditionally been overlooked by pharmaceutical companies. They are usually looking for the next blockbuster drug, so the lack of a large patient pool means they may not generate the revenue needed to justify the R&D financial […]

Molecular Detectives: discovering new ion channels (II)

Molecular Detectives: discovering new ion channels (II)

BiologyBiomedicineGeneticsMolecular biology

By Sergio Laínez

The identification of previously unknown proteins is a difficult task and often requires to follow unconventional thinking. In my previous post, I have described how the TRPV1 ion channel (formerly known as the capsaicin receptor) was discovered by combining the construction of a cDNA library from primary afferent neurons (DRG neurons) and the functional selection […]

Molecular Detectives: discovering new ion channels (I)

Molecular Detectives: discovering new ion channels (I)

BiologyBiomedicineGeneticsMolecular biology

By Sergio Laínez

Doing research in molecular biology is not straightforward, because most of the experimental work is based in the study of molecules which cannot be seen by the unaided eye. Instead, we rely on indirect evidence given by methods which are specific for each area of research. Let’s focus here as an illustrative example at someone […]