Category archives: Biomedicine

A hunger peptide prevents weight loss in anorexic mice

A hunger peptide prevents weight loss in anorexic mice

Biomedicine

By Rosa García-Verdugo

Eating disorders such as anorexia nervosa affect up to 70 million people worldwide. In particular, despite its prevalence and long-term duration, there are no effective pharmacological treatments for anorexia. This may change in the future if recent results in mice transfer appropriately to humans, as a “hunger” peptide appears to revert weight loss in mice […]

Depletion of dendritic cells in established tumors suppresses immunotherapy efficacy

Depletion of dendritic cells in established tumors suppresses immunotherapy efficacy

Biomedicine

By Invited Researcher

The ability to uptake cellular debris and process the engulfed antigens for MHC class I presentation is mainly performed by a minority subset of dendritic cells . Immunologists identified them as “conventional-type 1 dendritic cells”, and characterized them identifying the presence of surface coexpression of CD11c, XCR1, and DNGR-1 molecules . In mice, two subsets […]

TRAF6 functions as a tumor suppressor in myeloid malignancies

TRAF6 functions as a tumor suppressor in myeloid malignancies

Biomedicine

By Invited Researcher

Hematopoietic stem cells (HSC) accumulate somatic mutations during ageing in healthy individuals . Despite most of these mutations are inconsequential, some HSC can acquire specific mutations providing a competitive advantage leading to a process known as “clonal hematopoiesis of indeterminant potential” (CHIP) . The most common CHIP mutations affects to DNMT3A and TET2 genes and […]

Adipocytes orchestrate T-cell acute lymphoblastic leukemia propagation

Adipocytes orchestrate T-cell acute lymphoblastic leukemia propagation

Biomedicine

By Invited Researcher

T-cell acute lymphoblastic leukemia (T-ALL) is a devastating disease of T-cell progenitors that mainly affects children and young adults. Numerous genomic alterations are known to induce survival, proliferation, and differentiation of T-ALL cells . The interactions between leukemic cells and their microenvironment are known factors that contribute to T-ALL pathogenesis. The bone marrow (BM) microenvironment […]

CASZ1 promotes T-cell acute lymphoblastic leukemia

CASZ1 promotes T-cell acute lymphoblastic leukemia

Biomedicine

By Invited Researcher

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that results from transformation and clonal expansion of developmentally-arrested T-cell progenitors . Conventional risk-adjusted multi-agent chemotherapy allows for high 5-year event-free survival rates in children. However, a significant number of patients still relapse or do not respond to therapy. Consequently, there have been considerable efforts […]