T-cell acute lymphoblastic leukemia (T-ALL) is characterized by the accumulation of genetic lesions that induce differentiation arrest, survival and aberrant proliferation of immature T-cell progenitors . Although T-ALL prognosis has significantly improved due to intensive chemotherapy, relapses still occur in 20% of pediatric patients and 50% of adult patients, often with a dismal outcome. To […]
Acute myeloid leukemia (AML) is a hematological malignancy arising from the occurrence of genetic mutations in hematopoietic progenitors, which cause a blockage in the maturation and an uncontrolled growth of leukemic blasts in the bone marrow (BM). The resistance to current therapies and relapse remain a major clinical challenge. For this reason, a novel approach […]
Aging is inevitable, but not all forms of aging are the same. While some people reach old age in good physical and mental health, others suffer a progressive decline that affects their quality of life. What if there was a way to tip the balance toward healthier aging? A group of researchers from several scientific […]
Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal expansion of plasma cells in the bone marrow (BM) . Nearly 90% of myeloma patients suffer from skeletal-related events during the course of the disease that not only affect the quality of life but also their overall survival . Myeloma-associated bone disease (MBD) is […]
One of the most famous quotes that Santiago Ramón y Cajal wrote in his work “Rules and tips on scientific research” was “Every man can, if he so desires, become the sculptor of his own brain.” . However, the use of dental material as mud and stones to model or repair sculptures probably sounded like […]
Eating disorders such as anorexia nervosa affect up to 70 million people worldwide. In particular, despite its prevalence and long-term duration, there are no effective pharmacological treatments for anorexia. This may change in the future if recent results in mice transfer appropriately to humans, as a “hunger” peptide appears to revert weight loss in mice […]
Acute myeloid leukemia (AML) is a disease of older persons that has a dismal outcome and patients unfit for intensive chemotherapy exhibit a median survival of only 5 to 10 months . However, the therapeutic landscape of AML is changing with the appearance of new-targeted drugs such as BH3 mimetics that inhibit prosurvival BCL2 family […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Schizophrenia is a chronic and […]
The ability to uptake cellular debris and process the engulfed antigens for MHC class I presentation is mainly performed by a minority subset of dendritic cells . Immunologists identified them as “conventional-type 1 dendritic cells”, and characterized them identifying the presence of surface coexpression of CD11c, XCR1, and DNGR-1 molecules . In mice, two subsets […]
Hematopoietic stem cells (HSC) accumulate somatic mutations during ageing in healthy individuals . Despite most of these mutations are inconsequential, some HSC can acquire specific mutations providing a competitive advantage leading to a process known as “clonal hematopoiesis of indeterminant potential” (CHIP) . The most common CHIP mutations affects to DNMT3A and TET2 genes and […]