Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Schizophrenia is a chronic and […]
The ability to uptake cellular debris and process the engulfed antigens for MHC class I presentation is mainly performed by a minority subset of dendritic cells . Immunologists identified them as “conventional-type 1 dendritic cells”, and characterized them identifying the presence of surface coexpression of CD11c, XCR1, and DNGR-1 molecules . In mice, two subsets […]
Hematopoietic stem cells (HSC) accumulate somatic mutations during ageing in healthy individuals . Despite most of these mutations are inconsequential, some HSC can acquire specific mutations providing a competitive advantage leading to a process known as “clonal hematopoiesis of indeterminant potential” (CHIP) . The most common CHIP mutations affects to DNMT3A and TET2 genes and […]
T-cell acute lymphoblastic leukemia (T-ALL) is a devastating disease of T-cell progenitors that mainly affects children and young adults. Numerous genomic alterations are known to induce survival, proliferation, and differentiation of T-ALL cells . The interactions between leukemic cells and their microenvironment are known factors that contribute to T-ALL pathogenesis. The bone marrow (BM) microenvironment […]
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that results from transformation and clonal expansion of developmentally-arrested T-cell progenitors . Conventional risk-adjusted multi-agent chemotherapy allows for high 5-year event-free survival rates in children. However, a significant number of patients still relapse or do not respond to therapy. Consequently, there have been considerable efforts […]
Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the uncontrolled expansion of the immature myeloid cells . The 5-year survival rates of young patients are 40–50% and less than 15% for patients aged over 60 . For this reason, a great effort has been made to decipher the molecular events underlying AML […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. There is strong evidence that […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. The research group of Wang […]
Acute myeloid leukemia (AML) is a stem cell disease caused by the massive mobilization and differentiation arrest in primordial granulocytes. AML is characterized by a low survival rate and high recurrence . Although differentiation-induction therapy represents an innovative treatment strategy for AML , many problems still exist, including irreversible resistance, toxic effects, and limitations of […]
Acute B-cell progenitor acute lymphoblastic leukemia (B-ALL) is a clonal hematopoietic neoplasm characterized by the proliferation and accumulation of B-lymphoid progenitor cells throughout the bone marrow. Although important studies have characterized the underlying biological pathways that underpin therapy failure , resistance and subsequent relapse remain a leading cause of cancer-related deaths . One approach to […]