Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal expansion of plasma cells in the bone marrow (BM) . Nearly 90% of myeloma patients suffer from skeletal-related events during the course of the disease that not only affect the quality of life but also their overall survival . Myeloma-associated bone disease (MBD) is […]
One of the most famous quotes that Santiago Ramón y Cajal wrote in his work “Rules and tips on scientific research” was “Every man can, if he so desires, become the sculptor of his own brain.” . However, the use of dental material as mud and stones to model or repair sculptures probably sounded like […]
Eating disorders such as anorexia nervosa affect up to 70 million people worldwide. In particular, despite its prevalence and long-term duration, there are no effective pharmacological treatments for anorexia. This may change in the future if recent results in mice transfer appropriately to humans, as a “hunger” peptide appears to revert weight loss in mice […]
Acute myeloid leukemia (AML) is a disease of older persons that has a dismal outcome and patients unfit for intensive chemotherapy exhibit a median survival of only 5 to 10 months . However, the therapeutic landscape of AML is changing with the appearance of new-targeted drugs such as BH3 mimetics that inhibit prosurvival BCL2 family […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Schizophrenia is a chronic and […]
The ability to uptake cellular debris and process the engulfed antigens for MHC class I presentation is mainly performed by a minority subset of dendritic cells . Immunologists identified them as “conventional-type 1 dendritic cells”, and characterized them identifying the presence of surface coexpression of CD11c, XCR1, and DNGR-1 molecules . In mice, two subsets […]
Hematopoietic stem cells (HSC) accumulate somatic mutations during ageing in healthy individuals . Despite most of these mutations are inconsequential, some HSC can acquire specific mutations providing a competitive advantage leading to a process known as “clonal hematopoiesis of indeterminant potential” (CHIP) . The most common CHIP mutations affects to DNMT3A and TET2 genes and […]
T-cell acute lymphoblastic leukemia (T-ALL) is a devastating disease of T-cell progenitors that mainly affects children and young adults. Numerous genomic alterations are known to induce survival, proliferation, and differentiation of T-ALL cells . The interactions between leukemic cells and their microenvironment are known factors that contribute to T-ALL pathogenesis. The bone marrow (BM) microenvironment […]
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that results from transformation and clonal expansion of developmentally-arrested T-cell progenitors . Conventional risk-adjusted multi-agent chemotherapy allows for high 5-year event-free survival rates in children. However, a significant number of patients still relapse or do not respond to therapy. Consequently, there have been considerable efforts […]
Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the uncontrolled expansion of the immature myeloid cells . The 5-year survival rates of young patients are 40–50% and less than 15% for patients aged over 60 . For this reason, a great effort has been made to decipher the molecular events underlying AML […]