T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a poor prognosis and limited options for targeted therapies . Since the targeted therapies benefiting T-ALL are still limited owing to the biological heterogeneity of T-ALL , identifying novel “druggable” molecular markers and illustrating the underlying mechanisms are immediate pressing issues in T-ALL […]
Throughout the relentless struggle against cancer, conventional medicine has largely depended on aggressive methods of elimination—surgical removal, radiation, and chemotherapy—aimed at eradicating malignant cells before they can overwhelm the patient. While these approaches have proven effective in many cases, they often come at a steep cost, damaging healthy tissue and leaving patients vulnerable to recurrence […]
Acute myeloid leukemia (AML) with t(6;9)/DEK::NUP214 is recognized as a separate entity in the World Health Organization classification of myeloid neoplasms, accounting for 1% of all AML cases and characterized by a high relapse rate and young age at diagnosis . The t(6;9) chromosomal rearrangement results in the fusion of almost the entire peptide sequence […]
Authors: Gráinne Tyrrell, Doctoral Researcher in Biomedical Device Design, School of Architecture and Product Design, University of Limerick; Eoin White, Associate Professor of Medtech Design, University of Limerick, and Leonard O Sullivan, Professor in Ergonomics and Human Factors, Department of Science and Engineering, University of Limerick “If you can’t handle this, you’ll never keep up […]
T-cell acute lymphoblastic leukemia (T-ALL) is characterized by the accumulation of genetic lesions that induce differentiation arrest, survival and aberrant proliferation of immature T-cell progenitors . Although T-ALL prognosis has significantly improved due to intensive chemotherapy, relapses still occur in 20% of pediatric patients and 50% of adult patients, often with a dismal outcome. To […]
Acute myeloid leukemia (AML) is a hematological malignancy arising from the occurrence of genetic mutations in hematopoietic progenitors, which cause a blockage in the maturation and an uncontrolled growth of leukemic blasts in the bone marrow (BM). The resistance to current therapies and relapse remain a major clinical challenge. For this reason, a novel approach […]
Aging is inevitable, but not all forms of aging are the same. While some people reach old age in good physical and mental health, others suffer a progressive decline that affects their quality of life. What if there was a way to tip the balance toward healthier aging? A group of researchers from several scientific […]
Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal expansion of plasma cells in the bone marrow (BM) . Nearly 90% of myeloma patients suffer from skeletal-related events during the course of the disease that not only affect the quality of life but also their overall survival . Myeloma-associated bone disease (MBD) is […]
One of the most famous quotes that Santiago Ramón y Cajal wrote in his work “Rules and tips on scientific research” was “Every man can, if he so desires, become the sculptor of his own brain.” . However, the use of dental material as mud and stones to model or repair sculptures probably sounded like […]
Eating disorders such as anorexia nervosa affect up to 70 million people worldwide. In particular, despite its prevalence and long-term duration, there are no effective pharmacological treatments for anorexia. This may change in the future if recent results in mice transfer appropriately to humans, as a “hunger” peptide appears to revert weight loss in mice […]