DNA damage is one of the most deleterious forms of cellular damage. If unrepaired, DNA lesions can create genomic instability, a hallmark of cancer . As most of the DNA is confined to the nucleus, for many years the study of DNA damage response has mainly focused on its nuclear effects, including mechanisms such as […]
‘Yo soy yo y mi circumstancia, y si no la salvo a ella no me salvo yo’ José Ortega y Gasset (Meditaciones del Quijote, 1914) In my first article for Mapping Ignorance I stated that “destiny” was an unrealistic concept disproved by the scientific evidence. However, it could be possible that this is not completely […]
The last advances in genetics and genomics are leading a change in the paradigm about how to treat diseases. Epigenetics is the science field that studies how gene expression is regulated. Several modifications on the genes such as DNA-methylation, histone-acetylation or microRNA (miRNA) regulation are considered to be the main responsible in controlling gene expression […]
Under the threat of those annoying genetic parasites called viruses, eukaryotic cells developed, on the top of a wide innate defence, a curious and efficient RNA-based adaptive immune system referred as RNA interference or iRNA. You will find more info about this surveillance system, which detects and destroys foreign RNA molecules entering the cell with […]
The idea of a living fossil is rather intuitive. We think that a kind of organism deserves that denomination if it has been living in the planet during a very large period of time apparently without any change. A well known example of living fossil is the Ginkgo tree (Ginkgo biloba) because, although it is […]
Although we assume evolution of complex life forms as a matter of fact, we must admit that our brains are not ready for such an odd concept. Even though we can slightly imagine what a million year means, when we finally stare at some amazing life beings, we cannot fully comprehend the changes needed over […]
Nowadays there are still people that believe in destiny. However the scientific community more and more is bringing light to that subject showing that although the genetic material could program ourselves to suffer some pathologies, the day-to-day experiences are the ones that lead us towards a healthy or pathological aging. And how is that? Our […]
Think on a cell, it is alive and, among other things, it lives to reproduce itself. The paradigm of cell division is the mitosis, a wonderful dance orchestrated to equitably distribute the possessions of the mother cell: molecular structures, machinery and, especially, the genetic material. Prior to distribute, a good mother always amasses a fortune […]
How are we like we are? What defines our mind, our character, and our behaviour? Men made themselves these questions in all ages of humanity. From the age of myths to the age of science the answers have been very many. We do not have an adequate answer yet, maybe never. However, the rise of […]
There is a strong tendency to consider that every scientific or technical solution to a particular problem is irrefutable. Nowadays, scientific and technological knowledge usually eludes public criticism and even we have seen how important government decision making were made by the so-called technocrats . We often forget the contingency of this knowledge, the fact […]