Many (if not most) clinical trials end up failing, but given the bias towards positive results sometimes the reasons for their not working remain unclear. Luckily, a team at Open Targets and EMBL’s European Bioinformatics Institute (EMBL-EBI) have analysed the reasons for aborted clinical trials mentioned in Clinicaltrials.gov, the open-source register for clinical trials worldwide […]
Biology • Biomedicine • Medicine • Pharmacy
One of the biggest health threats in our current society is not related to a virus, not even to diabetes or cardiovascular disease, but to antimicrobial resistance. In fact, over 5 million deaths per year are associated with resistant bacteria, of which nearly 1.3 million deaths per year are directly attributable to antimicrobial resistance. This […]
The recent COVID-19 pandemic has demonstrated the vulnerabilities of our society to infectious diseases and the limitations of the tools available for viruses detection. Polymerase chain reaction (PCR) and antigens tests have been useful to monitor and contain the extension of the last pandemic, however it demonstrated to have severe limitations. PCR is a highly […]
Computer science • Language • Linguistics • Medicine • Robotics
At a time when the mass media are full of predictions about the apocalyptic effect that AI will have on humanity, it is comforting to read two essays that show that the reality, for the moment, points in the opposite direction. The first of these reveals the excellent results that the application of natural language […]
Health • Medicine • Physiology • Psychology
gender gap Sleep experts recommend that adults sleep 7-9 h per night (7-8 h for older adults). However, about 30-35% of adults sleep less than 7 h and prevalence rates of short or insufficient sleep are increasing. Insufficient sleep is not in itself a diagnosable disorder; however, its high prevalence highlights a key target for […]
Biochemistry • Biomedicine • Health • Medicine • Neuroscience
Recent research has demonstrated that obesity impairs the mechanisms that allow our brains to realize when our stomachs are full and that these changes are maintained despite dieting, giving insights into why it is difficult for obese people to avoid excessive eating and why there is often a yo-yo effect after dieting. It has been […]
Cancers are the second leading cause of death in the world, after cardiovascular diseases. Their seriousness lies in their diversity – some can be effectively treated with surgery, chemotherapy and radiotherapy, while others respond poorly or not at all. Improving the treatment of these diseases is therefore a major challenge. For several years, the development […]
Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter involved in various cognitive and affective functions. Drugs targeting serotonin transmission, such as selective serotonin reuptake inhibitors (SSRIs), are the first-line pharmacological treatments for many neuropsychiatric disorders such as major depressive disorder, obsessive-compulsive disorder and anxiety. These antidepressants increase the concentration in the synaptic space of this neurotransmitter […]
madness Authors: Chiara Bressan, student of the European Master’s in Clinical Linguistics & Adrià Rofes, assistant professor of neurolinguistics at the University of Groningen Imagine yourself tied to a chair. You cannot move, you are fully conscious, and a strange individual behind you is about to carve into your skull. No, you are not an […]
Intermittent fasting, that is, eating only over a certain time period during the day, can have positive mental health effects, at least according to a recent study . Intermittent fasting for 16 hours a day, that is a 16:8 fasting paradigm, for five days a week during three months improved quality of life while decreasing […]