The Nuclear Receptors in Cancer, Metabolism and inflammation network
Estrogens are steroid hormones affecting several organs including mammary glands. More precisely, these glands exert their action by means of estrogens through the e strogen receptor (ER), a transcription factor belonging to the family of nuclear receptors. So far, two types of ERs have been identified: alpha and beta. ER-beta is expressed in all mammary […]
During the Cold War the competition between both sides, Russia and the United States of America, caused a quick development of military and spacial technology: while the Soviet Union was the first country responsible for an orbital launch (Sputnik 1), the first nation to ever send a man to space and pioneered spacewalks, the U […]
Like the river of Heraclitus, our bones are constantly changing. Although it may look tough and immutable , the bone is a very dynamic tissue that is constantly formed and destroyed, having different appearances during each of the stages of life. Bone destruction or reabsorption is mediated by a particular cellular type known as the […]
The mineralocorticoid receptor (MR) is an atypical nuclear receptor. In principle, it may seem a mere receptor with a specific ligand and an evident role: it is capable of detecting mineralocorticoids (like aldosterone), exerting an essential function controlling sodium and water reabsorption in the kidneys. In fact, knockout mice lacking MR die shortly after being […]
«BPA-Free», «No Bisphenol A» and similar labels have become a sort of seal of quality for those products where they are on display, especially containers and baby products. But, what is bisphenol A? In 1936 bisphenol A (BPA) was identified as a synthetic estrogen, this is, an artificial compound that shows estrogen-mimicking action. Estrogens are […]
Vitamin D is an atypical vitamin because it is not a real vitamin. Vitamins are supposed to be essential, meaning that our organism cannot live without them but their synthesis cannot take place in our cells, so we must ensure an external intake through the diet. However, only 10% of vitamin D daily requirements come […]
The study of nuclear receptors includes a great variety of approaches and techniques: from experiments with transgenic mice assessing their roles in the organism, to three-dimensional methods at the atomic level, in which the position of each amino acid and its function are examined. Dr. Estébanez’s research line focuses in the latter feature. T he […]
Our immune system comprises a great variety of cell types and each of these groups is specialized in separate and defined actions. Macrophages play an essential role within this defence system by enhancing the immune response. In particular, they are in charge of “swallowing” (technically speaking, fagocyting) waste products, foreign materials and microorganisms. In addition […]
W orld Health Organization (WHO) established the recognition of obesity as a disease in 1948, but it was not until the last decade of the 20th century that people began to gain awareness of overweight-derived health problems. A decade ago and based on worldwide data indicating that 40 % of global adult population were overweight […]
Collagen is the newest trendy nutrient. If we search for “collagen” in the web browser, we will find a wide variety of food supplements, cosmetic products and web pages where collagen beneficial effects are highlighted. Although collagen is a mere protein, its name is currently associated to the wellness circuit and, for this reason, it […]