One of the biggest difficulties of bringing new therapeutic methods into clinical practice is targeted delivery. A recent study shows the potential of using a gel for topical gene therapy. Recessive dystrophic epidermolysis bullosa is a genetic disease that affects proper skin formation. The affected people have an extremely fragile skin, which often suffers from […]
Cod “supergenes” have shed light on how they respond to overfishing, and these supergenes could make them more resilient to other environmental changes. That’s according to a new study published by scientists in Norway. This could be good news, in that cod have genetic architecture in place that will permit them to respond to climate […]
Since the beginning of the COVID-19 pandemic, there were hints at particular genes which increased some people’s susceptibility to get infected and the severity of illness once infected. Now, an international study (nearly 3500 researchers from 25 countries) on more than 45000 people infected with SARS-CoV-2, showed a link between 13 genetic variants and the […]
A significant portion of an organism’s genome is non-coding; that is, it does not carry information to make proteins. Part of the non-coding DNA is transcribed into functional non-coding RNA molecules (e.g., transfer RNA, ribosomal RNA and regulatory RNA). Other functions of non-coding DNA include transcriptional and translational regulation of protein coding sequences, nuclear scaffold […]
Gene editing could be the solution to progeria, a genetic disease, characterized by extremely fast ageing. Progeria causes fast ageing and premature death in people carrying a single-point mutation in the LMNA gene, which basically leads to the production of a toxic protein which slowly damages the cells, ageing the bodies. This simple misspelling of […]
Mitochondria are the energy-making machines in the cell. Also, since evolutionarily they are thought to evolve from symbiotic bacteria, they have their own little genomes, which are mainly evolved through the maternal side, and also maybe because of their important function, mutations in genes affecting them are very damaging, and even lethal. However, mitochondrial DNA […]
A middle-aged white man raises his sword to the skies and roars to the gods. The results of his genetic ancestry test have just arrived in his suburban mailbox. His eyes fill with tears as he learns that he is “0.012% Viking”. These are the scenes from a video advertisement for the TV-series Vikings. This […]
Computer science • Genetics • Health • Medicine • Molecular biology • Pharmacy
A number of technologies and tools got a chance to prove themselves for the first time in the context of COVID-19. Three researchers working in gene-based vaccines, wearable diagnostics and drug discovery explain how their work rose to the challenge of the pandemic, and their hopes that each technology is now poised to continue making […]
Hollywood blockbusters such as X-men, Gattaca and Jurassic World have explored the intriguing concept of “germline genome editing” – a biomolecular technique that can alter the DNA of sperm, eggs or embryos. If you remove a gene that causes a certain disease in an embryo, not only will the baby be free of the disease […]
Loss of gene function is a common occurrence in evolution that is usually associated with loss of fitness. However, it seems that as many say: “where there’s a problem, there is an opportunity“, for as researchers from Leuven University led by Rob Jelier have recently reported , gene loss was found to drive adaptation. To […]