Category archives: Pharmacy

Against a failing heart, pharmacoepigenomics

Against a failing heart, pharmacoepigenomics

GeneticsPharmacy

By Eduardo Oliver

The last advances in genetics and genomics are leading a change in the paradigm about how to treat diseases. Epigenetics is the science field that studies how gene expression is regulated. Several modifications on the genes such as DNA-methylation, histone-acetylation or microRNA (miRNA) regulation are considered to be the main responsible in controlling gene expression […]

Lead-oriented synthesis: a new concept to aid drug-discovery process

Lead-oriented synthesis: a new concept to aid drug-discovery process

ChemistryMedicinePharmacy

By Pablo Ortiz

The discovery and development of new drugs is a long and expensive process, and despite of it, essential to face present and new diseases. For small molecules, which account for the majority of the marketed drugs, the discovery process generally involves finding a starting point termed hit or lead compound. These molecules have biological activity […]