Economics • Mathematics • Medicine • Pharmacy
Blood from donations is separated into three components: red cells, platelets and plasma, and one component or another is then transfused into patients according to their needs. The conditions for storage differ for each component: red cell concentrates can be kept for up to 42 days at temperatures of 1-6ºC. Platelet concentrates (PC) are stored […]
Suicide is one of the worst health and social problems in the modern world. Hundreds of millions of persons experience suicidal thoughts every year and between 10 and 20 millions went on to attempt suicide. In Spain, although the average risk is lower than in Northern countries, almost 4.000 persons die every year by their […]
Some pharmaceutical painkillers and analgesics like Noscapine, papaverine and tubocurarine or the most famous opioids codeine or morphine are Benzylisoquinoline derivatives. Few of them are used daily for thousands of people to relieve a variety of physical pains. However, due to their rather complex biosynthesis, they are still obtained by processing plant extracts (mainly from […]
Enantiomers are any two molecules that are mirror images of each other, in the same way that, within a same person, left and right hands are: both hands look exactly the same but indeed they are not, as they cannot be superimposed. This is very easily seen when we try to put the wrong glove […]
There is a widespread concern about the increasing antibiotic resistance and the limited new drugs to treat infectious diseases, as discussed in a previous post . Consequently, the discovery of a new antibiotic active against a range of bacterial pathogens including Staphylococcus aureus has been greatly welcome, especially because no resistance to it has been […]
Most people in Spain have heard about the ongoing bitter polemic between the Victims of Hepatitis C Platform and the Spanish government with regard to the access to a new medication called Sovaldi approved by the Spanish government last 1st October. The main reason for such clash between them is simple: the asking price for […]
The Ebola outbreak has brought the fear of a viral pandemic to the headlines once more, as it happened before with the avian or swine flu. Although viruses-caused infections catch most of attention on the media, the greatest risk to human health comes from other microorganisms, the antibiotic-resistant bacteria. Contrary to viral outbreaks, the threat […]
The last advances in genetics and genomics are leading a change in the paradigm about how to treat diseases. Epigenetics is the science field that studies how gene expression is regulated. Several modifications on the genes such as DNA-methylation, histone-acetylation or microRNA (miRNA) regulation are considered to be the main responsible in controlling gene expression […]
The discovery and development of new drugs is a long and expensive process, and despite of it, essential to face present and new diseases. For small molecules, which account for the majority of the marketed drugs, the discovery process generally involves finding a starting point termed hit or lead compound. These molecules have biological activity […]