In a paper led by Passaro and coworkers we sought to identify a functional link between the activity of a protein called calcineurin and the response of a type of leukemic cells known as “T-ALL” to microenvironmental signals. Furthermore, we wanted to determine whether interrupting these signals could affect to leukemia development, thus providing alternative […]
Gene editing could be the solution to progeria, a genetic disease, characterized by extremely fast ageing. Progeria causes fast ageing and premature death in people carrying a single-point mutation in the LMNA gene, which basically leads to the production of a toxic protein which slowly damages the cells, ageing the bodies. This simple misspelling of […]
As more and more people around the world are getting vaccinated, one can almost hear the collective sigh of relief. But the next pandemic threat is likely already making its way through the population right now. My research as an infectious disease epidemiologist has found that there is a simple strategy to mitigate emerging outbreaks: […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Research in oncology advances very […]
Inherited or somatic mutations targeting genes which encode essential cell growth regulatory proteins favor the emergence of cancer. Cells carrying these mutations acquire growing and survival advantages that trigger the emergence of the tumor. A large number of tumor-associated mutations, as well as many mutations found in the germline of hereditary cancer patients, are single-nucleotide […]
Gliomas are the most prevalent subtype of primary brain tumours originating from mutations of the glia cells in the central nervous system. Gliomas are characterized by fast cell growth, strong invasion capability, and well-developed tumour vasculature. Although research and clinical trials have allowed significant progress in the comprehension and treatment of gliomas, they still have […]
The close interconnection between the gut and the central nervous system is already well described, what is new is the possibility of some of the brain’s defense systems originating in the gut. New research in mice published in the journal Nature found that immune cells are first trained in the gut and then migrate to […]
The intranasal route is a rapid, efficient and direct way for different biological agents, small molecules, drugs and chemical compounds to reach the brain. It seems amazing, but people that snort a line of coke already knew that… To date, its mechanism of diffusion is believed to be using either olfactory nerve tracts or dense […]
“ The dose makes the poison!” This adage, attributed to Paracelsus, explains a basic principle of toxicology: a substance can produce a harmful effect only if it reaches a certain “toxic” concentration. [ 1 ] In reverse, it also means that a substance is not harmful below this toxic dose, and can even be vitally […]
It seems that the genetic risk of an APOE4 variant in the APOE gene would not only increase risk for Alzheimer’s but also would increase the chances of getting infected by the COVID-19 virus. The APO protein is involved in cholesterol metabolism and the immune system. However, its precise role in Alzheimer’s disease is as […]