Author Archives: Isabel Perez Castro

<span property="name">Isabel Perez Castro</span>
Isabel Pérez-Castro obtained her PhD in chemistry at the University of Santiago de Compostela where she completed her thesis on the synthesis of non-natural nucleosides. She then moved to the UK where she has worked in tuberculosis drug discovery at the University of Cambridge, as well as in cancer drug research at Queen Mary, University of London and the Bart's Institute of Cancer. She is now focused on new drug discovery at Magnus Life Science, associated to the Wolfson Institute for Biomedical Research - UCL.

“It is often said that all the conditions for the first production of a living organism are now present, which could ever have been present.— But if (& oh what a big if) we could conceive in some warm […]

From nucleic acids to proteins and sugar chains, all life is made up of polymers, large molecules made up of sequences of small units called monomers. However, how these macromolecules first appeared on the surface of Earth is still controversial. […]

Lipinski’s “rule of five”,1 very well known by medicinal chemists, has been defined as a set of rules, based on the number 5 -hence its name-, to evaluate the “drug-likeness” of a given molecule. The rules are:
– The […]

The haploid human genome contains approximately 3,000,000,000 base pairs of DNA packaged into 23 chromosomes. Most cells in the body, except for eggs and sperm, are diploid, with 23 pairs of chromosomes. That makes a total of 6,000,000,000 base pairs […]

The immune system is a complex network that recognises foreign substances in the body. When it detects an alien substance (antigen), it creates antibodies to attack and destroy it. This system protects vertebrates against viruses, bacteria, fungi and […]

The question of how human interaction works is a neurochemical one, but it’s not easy to solve. While many experiments cannot be performed on humans or primates, smaller laboratory animals are useless for this research due to their differences with […]

When we talk about nucleic acids we generally think of DNA and RNA that code for proteins, and when we talk about brain cells we tend to think of neurons and their nerve impulse transmission. However, it is not news […]

Cell signalling is the mechanism by which cells communicate with each other and with their environment. Stimuli, which are generally chemical, are transmitted via a signalling cascade to effector molecules that orchestrate the appropriate response. Signalling pathways are not isolated […]

15% of human cancers worldwide may be attributed to viruses,1 with both DNA and RNA viruses being capable of causing the disease. Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA […]

The finding that modern humans coexisted and mated with Neanderthals 50000 years ago was a breakthrough when it was announced in 2010. As a result of interbreeding, the genomes of all modern Eurasians contain a small Neanderthal DNA load that […]