The study of nuclear receptors includes a great variety of approaches and techniques: from experiments with transgenic mice assessing their roles in the organism, to three-dimensional methods at the atomic level, in which the position of each amino acid and its function are examined. Dr. Estébanez’s research line focuses in the latter feature. T he […]
When we hear somebody wheezing, coughing, showing chest tightness and shortness of breath, most of us will immediately recognize the underlying cause: Asthma . This is not a minor issue, but one affecting approximately 5% of the entire world population (and steeply growing every year) and causing the death of nearly 400000 people back in […]
Our immune system comprises a great variety of cell types and each of these groups is specialized in separate and defined actions. Macrophages play an essential role within this defence system by enhancing the immune response. In particular, they are in charge of “swallowing” (technically speaking, fagocyting) waste products, foreign materials and microorganisms. In addition […]
The immune system is a complex network that recognises foreign substances in the body. When it detects an alien substance (antigen), it creates antibodies to attack and destroy it. This system protects vertebrates against viruses, bacteria, fungi and other parasites, and is the reason for the “rejection” after organ transplants. When we have cancer, our […]
W orld Health Organization (WHO) established the recognition of obesity as a disease in 1948, but it was not until the last decade of the 20th century that people began to gain awareness of overweight-derived health problems. A decade ago and based on worldwide data indicating that 40 % of global adult population were overweight […]
Collagen is the newest trendy nutrient. If we search for “collagen” in the web browser, we will find a wide variety of food supplements, cosmetic products and web pages where collagen beneficial effects are highlighted. Although collagen is a mere protein, its name is currently associated to the wellness circuit and, for this reason, it […]
There are plenty of examples of drugs that have been repurposed in recent years. For instance, thalidomide, the initially prescribed medication for headache in pregnant women which led to countless numbers of babies born with body malformations during the 50s and 60s, now this drug is used for treating certain types of cancer, such as […]
Interior of a human blood vessel. Something looks wrong, very wrong. Bacteria have entered the circulation, and the immunological system is reacting. All the alarms are on fire, while an army of white blood cells comes by, getting ready to unleash hell on the invaders. Suddenly, among these security agents, a neutrophil stands out. It […]
Diagnosis is one of the trickiest steps in disease management for many diseases, ranging from some types of cancer to rare diseases or neurodegenerative disorders, like Alzheimer’s for instance. Even though we have been hearing long about the disease, to date the only reliable diagnosis comes from a postmortem brain analysis and the finding of […]
The immune system is composed of a considerable variety of cell types with different functions. One of the most important cells involved in the innate immunity are the macrophages . These cells have a wide spectrum of functions: from bacteria-killing function to wound healing properties. Classically the macrophages according to their functions have been classified […]