The identification of previously unknown proteins is a difficult task and often requires to follow unconventional thinking. In my previous post, I have described how the TRPV1 ion channel (formerly known as the capsaicin receptor) was discovered by combining the construction of a cDNA library from primary afferent neurons (DRG neurons) and the functional selection […]
Doing research in molecular biology is not straightforward, because most of the experimental work is based in the study of molecules which cannot be seen by the unaided eye. Instead, we rely on indirect evidence given by methods which are specific for each area of research. Let’s focus here as an illustrative example at someone […]
Author: Shu Ning got her BSc degree in Pharmacy from Shenyang Pharmaceutical University (China) in 2014. In 2016, she obtained her Master of Research degree on Clinical Research – Translational Medicine – at Imperial College London (UK) where she has worked on mitochondrial dysfunction in pulmonary smooth muscle cells from Pulmonary Arterial Hypertension. Currently she […]
Celiac Disease (CD) is an autoimmune disease that is developed in susceptible individuals when the gluten is present in their diet. As consequence, there is an inflammation of the small intestine, what has different effects, such as pain and diarrhoea, and the only effective treatment known is a gluten-free diet. A great portion of the […]
A chemical compound or molecule consisting of two identical simpler molecules is a dimer. If one of the simpler molecules is excited while the other is in its ground, non-excited, state we talk about excimers. They are excited dimers which are non-bonding in the ground state. Thus, excimers can be considered evanescent quasi-particles that typically […]
The stem cell research field shocked the scientific community back in 2006 thanks to Shinya Yamanaka, who found a way to obtain pluripotent stem cells from adult somatic cells . The recipe consisted of just four genes encoding for transcription factors allowing him to reprogram mouse fibroblasts into induced pluripotent stem cells (iPSCs). The “Yamanaka […]
Around 80% of the single nucleotide polymorphisms (SNPs) associated to many human diseases map to non-coding regions. Long non-coding RNAs (lncRNAs) represent a large portion of non-coding regions across the genome, however the link between the disease-associated SNPs on lncRNA expression or function, and the implications for disease, remain uncharacterized. Celiac disease is complex immune […]
Biology • Biomedicine • Health • Medicine
What are lysosomes doing inside your cells? When I was in High School my teacher used to say that lysosomes are only the trash bin of the cell. 20 years later we have discovered a dozen new functions that make this small organelle a core component of the cell. You may already know that the […]
Although it may sound illogical, destruction of cells is as essential as their creation in the course of proper formation, growth and development of multi-cellular organisms. For this reason, cells program deliberately their suicide through a very controlled process, named apoptosis (from the Greek, “fall off”). Our research group at the University of Tübingen, Germany […]
One of the worst things that can happen to someone that loves talking as much as I do is losing my voice. What to most people is just a temporary inconvenience -or a relief depending on who you ask- for some is a real hindrance. Patients that suffer from a permanent impairment to their ability […]