Unless you’ve been sitting in a cave for the last couple of years, you have probably heard about the new great promise of gene therapy: the gene editing CRISPR system. This new addition to the molecular biology toolbox is groundbreaking for what it implies. It does not simply “force in” a healthy copy of whichever […]
When we talk about nucleic acids we generally think of DNA and RNA that code for proteins, and when we talk about brain cells we tend to think of neurons and their nerve impulse transmission. However, it is not news that the functions of both non-coding genetic material and non-transmitting cells in the brain are […]
Behind the symmetrical shell of humans and vertebrates lies a profound asymmetry. Our bilaterality breaks down inside our body. Not only our viscera are organized asymmetrically. Also our brain and nervous system, whose general appearance seems symmetrical, present lateralized structure and functioning. Among cognitive systems for example, language, attention, emotional processing, working memory and executive […]
Biology • Biomedicine • Genetics • Medicine • Pharmacy
Patients suffering from rare diseases (defined by the European as those affecting less than 5 in 10000 people) have traditionally been overlooked by pharmaceutical companies. They are usually looking for the next blockbuster drug, so the lack of a large patient pool means they may not generate the revenue needed to justify the R&D financial […]
Pigmentations are among the clearest examples of phenotypic variation in many species. Hair, skin and eye colors are highly heritable and visible traits in humans. Blond hair is most commonly found in Northern and Central Europeans and their descendants. Nowadays it can be found spread in many parts of the world but it is particularly […]
The identification of previously unknown proteins is a difficult task and often requires to follow unconventional thinking. In my previous post, I have described how the TRPV1 ion channel (formerly known as the capsaicin receptor) was discovered by combining the construction of a cDNA library from primary afferent neurons (DRG neurons) and the functional selection […]
Doing research in molecular biology is not straightforward, because most of the experimental work is based in the study of molecules which cannot be seen by the unaided eye. Instead, we rely on indirect evidence given by methods which are specific for each area of research. Let’s focus here as an illustrative example at someone […]
Celiac Disease (CD) is an autoimmune disease that is developed in susceptible individuals when the gluten is present in their diet. As consequence, there is an inflammation of the small intestine, what has different effects, such as pain and diarrhoea, and the only effective treatment known is a gluten-free diet. A great portion of the […]
Since we were kids (unless under the spell of a creationist education), we have been told that genetics is the reason for the colour of our eyes, our hair, our height and whether we look more like mum or dad. In the last few years, it might seem to many that gene association studies have […]
Autism is a highly prevalent spectrum disorder of the neurodevelopment. It is characterized by impaired social interaction, alterations in verbal and non-verbal communication, and restricted and repetitive behaviors. Considering these main differences, it had been difficult to have good animal models since these interactions were initially defined for humans but scientists are nowadays developing different […]