In 1868, the famous, powerful and short French neurologist Jean-Martin Charcot, known as “the Napoleon of the Salpêtrière hospital”, described a new disease. He called it “sclerose en plaque” in reference to the numerous scars or sclerosis seen in the white matter of the brain and spinal cord. We now call it multiple sclerosis. Multiple […]
Clinical research has fundamentally discriminated women, assuming that they are nothing more than “small” men and therefore, drugs should work mostly the same if just adjusting the dose to their lower weight. However, this has been proven not to be the case. The physiology of the two sexes differs in several parameters, that is why […]
Electrical stimulation of the spinal cord can help recover mobility in some paralysed patients. However, the mechanism underlying this partial recovery of function remains unknown. A recent human study has confirmed the involvement of a group of cells previously identified in mice, paving the way to targeted treatments. In a recently published study in Nature […]
In 1906, Alois Alzheimer, a psychiatrist and neuroanatomist, reported “a peculiar severe disease process of the cerebral cortex” to a gathering of psychiatrists in Tübingen, Germany. The case was a 50-year-old woman who suffered from memory loss, delusions, hallucinations, aggression and confusion – all of which worsened until her untimely death five years later. In […]
Antidepressants are the mainstay for treating depression, but their use is clouded by doubts about their short-, medium- and long-term efficacy. This is not to say that we should not use them, as these drugs save lives in many cases, but a recent review reinforces these questions as it sees little difference in the quality […]
A single MRI scan of the brain using standard equipment could be enough to diagnose Alzheimer’s disease, according to new results. The research uses machine learning technology to look at structural features within the brain, including in regions not previously associated with Alzheimer’s. The advantage of the technique is its simplicity and the fact that […]
Multiple sclerosis (MS) is a debilitating autoimmune condition whereby neurons lose their myelin sheath leading to impaired neural transmission, neural degeneration and motor symptoms. Multiple factors have been considered to influence its development, like vitamin D, but now, a couple of studies have shown that the Epstein-Barr virus (EBV) is linked to multiple sclerosis. You […]
Acute leukemia is characterized by the proliferation and accumulation of hematopoietic progenitor cells (which are able to differentiate to create specialized cell types) in the bone marrow that impede normal blood production. D epending on the cell population affected, it can be classified in Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML). ALL starts […]
Witchcraft involves the use of magic or supernatural powers to harm others. In medieval and early modern Europe, where the term originated, those accused of witchcraft were usually women who were believed to have attacked their own community and often to be in communion with evil beings. Witchcraft powers were acquired by inheritance or initiation […]
Two years of battling COVID-19 has been bad news for tuberculosis (TB) programmes. Respiratory clinicians and researchers have had their time and focus directed elsewhere. And TB has taken advantage. In 2021, the number of TB deaths rose for the first time in over a decade. The barriers caused by lockdowns and overstretched healthcare systems […]