Pain is a complex sensation that is mediated by both the peripheral and central nervous systems. In the peripheral nervous system, pain signals are generated by nerve fibers called nociceptors that respond to harmful stimuli. These signals are then transmitted to the brain through the spinal cord, where they are processed and interpreted as pain […]
Occasionally I receive groups of messages from families with autistic members and I know the reason: they have read in the press exciting news about autism, a spectacular treatment, even a miracle cure. Unfortunately, if all that news were true we would have solved autism hundreds of times by now. So let’s start with the […]
For a long time, it was thought that dreaming occurred in the rapid eye movement phase of sleep (REM sleep). It is now well established that it can occur at any stage of sleep and, therefore, is not exclusive to a specific global vigilance state. Today, there is no known physiological correlate of a dream […]
Antidepressants are the mainstay for treating depression, but their use is clouded by doubts about their short-, medium- and long-term efficacy. This is not to say that we should not use them, as these drugs save lives in many cases, but a recent review reinforces these questions as it sees little difference in the quality […]
Witchcraft involves the use of magic or supernatural powers to harm others. In medieval and early modern Europe, where the term originated, those accused of witchcraft were usually women who were believed to have attacked their own community and often to be in communion with evil beings. Witchcraft powers were acquired by inheritance or initiation […]
mTOR has nothing to do with Norse mythology, it stands for “mammalian target of rapamycin” or “target of rapamycin in mammalian cells”. mTOR is involved in important cellular processes, including growth, proliferation, motility, survival, protein synthesis, transcription and autophagy. The history of rapamycin is so suggestive that I cannot avoid mentioning it: in the 1960s […]
At a synapse, the plasma membrane of the neuron transmitting the information (the presynaptic neuron) is in close proximity to the membrane of the target cell (postsynaptic) and the two are separated by a space known as the synaptic cleft. Both the presynaptic and postsynaptic sites contain extensive assemblies of molecular machinery that link the […]
A significant portion of an organism’s genome is non-coding; that is, it does not carry information to make proteins. Part of the non-coding DNA is transcribed into functional non-coding RNA molecules (e.g., transfer RNA, ribosomal RNA and regulatory RNA). Other functions of non-coding DNA include transcriptional and translational regulation of protein coding sequences, nuclear scaffold […]
If we look back at our past, we are all aware of how much we have changed. The innocence of our childhood, the impulses of our adolescence, the vehemence and passion of our youth, the tranquillity of our mature life: some of us already know what we will be like when we grow up! Hopefully […]
An earworm is a melody that arises spontaneously in the mind, perhaps after having heard it only once, and gets “stuck” in the head for hours or days. It is also called brainworm, catchy music, repetition of musical images, involuntary musical imagery and stuck song syndrome. We may come to feel that the tune is […]