Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently, he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Cell migration is key to […]
In 1906, Alois Alzheimer, a psychiatrist and neuroanatomist, reported “a peculiar severe disease process of the cerebral cortex” to a gathering of psychiatrists in Tübingen, Germany. The case was a 50-year-old woman who suffered from memory loss, delusions, hallucinations, aggression and confusion – all of which worsened until her untimely death five years later. In […]
Mostly, people think that an embryo can only (except in the case of parthenogenesis) result from the sum of sperm and an egg. However, two research teams, one in Israel and another multinational collaboration have recently reported producing a synthetic mouse embryo from stem cells which lasted enough to have a brain and a beating […]
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. This cancer is characterized by the rapid growth of immature myeloid precursors that occupy and alter the bone marrow (BM) niche where normal hematopoietic stems cells (HSCs) reside (the “niche” is the in vivo microenvironment where stem cells reside and receive […]
Multiple sclerosis (MS) is a debilitating autoimmune condition whereby neurons lose their myelin sheath leading to impaired neural transmission, neural degeneration and motor symptoms. Multiple factors have been considered to influence its development, like vitamin D, but now, a couple of studies have shown that the Epstein-Barr virus (EBV) is linked to multiple sclerosis. You […]
One of the biggest difficulties of bringing new therapeutic methods into clinical practice is targeted delivery. A recent study shows the potential of using a gel for topical gene therapy. Recessive dystrophic epidermolysis bullosa is a genetic disease that affects proper skin formation. The affected people have an extremely fragile skin, which often suffers from […]
Acute leukemia is characterized by the proliferation and accumulation of hematopoietic progenitor cells (which are able to differentiate to create specialized cell types) in the bone marrow that impede normal blood production. D epending on the cell population affected, it can be classified in Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML). ALL starts […]
Two years of battling COVID-19 has been bad news for tuberculosis (TB) programmes. Respiratory clinicians and researchers have had their time and focus directed elsewhere. And TB has taken advantage. In 2021, the number of TB deaths rose for the first time in over a decade. The barriers caused by lockdowns and overstretched healthcare systems […]
C ardiovascular diseases currently form the most important class of non-contagious diseases and a leading cause of mortality in industrialized nations . Specifically, coronary heart disease is the first cause of death among the cardiovascular diseases . The myocardial infarction (MI), commonly known as a “heart attack”, occurs when blood flow decreases or stops in […]
How an organism can sense and cope with warming temperatures is key for survival, particularly under current global warming trends. The importance of this subject was recognized by 2021’s Nobel prize in Physiology & Medicine awarded to work on TRP channels, key mammalian peripheral heat sensors. Endotherms -such as mammals and birds – maintain their […]