Category archives: Biomedicine

Nociceptor inhibition as a new therapeutic approach for asthma

Nociceptor inhibition as a new therapeutic approach for asthma

BiomedicineMedicineNeurobiologyPharmacy

By Sergio Laínez

When we hear somebody wheezing, coughing, showing chest tightness and shortness of breath, most of us will immediately recognize the underlying cause: Asthma. This is not a minor issue, but one affecting approximately 5% of the entire world population (and steeply growing every year) and causing the death of nearly 400000 people back in 2015 […]

Marginal macrophages and LXR: living on the edge

Marginal macrophages and LXR: living on the edge

BiomedicineMolecular biology

By NuRCaMein

Our immune system comprises a great variety of cell types and each of these groups is specialized in separate and defined actions. Macrophages play an essential role within this defence system by enhancing the immune response. In particular, they are in charge of “swallowing” (technically speaking, fagocyting) waste products, foreign materials and microorganisms. In addition […]

Antibody-drug conjugates, a fine example of teamwork

Antibody-drug conjugates, a fine example of teamwork

BiomedicineMolecular biologyPharmacy

By Isabel Perez Castro

The immune system is a complex network that recognises foreign substances in the body. When it detects an alien substance (antigen), it creates antibodies to attack and destroy it. This system protects vertebrates against viruses, bacteria, fungi and other parasites, and is the reason for the “rejection” after organ transplants. When we have cancer, our […]

The mystery of collagen and thyroid hormone: a detective story

The mystery of collagen and thyroid hormone: a detective story

BiomedicineMolecular biology

By NuRCaMein

Collagen is the newest trendy nutrient. If we search for “collagen” in the web browser, we will find a wide variety of food supplements, cosmetic products and web pages where collagen beneficial effects are highlighted. Although collagen is a mere protein, its name is currently associated to the wellness circuit and, for this reason, it […]

Using mass spectrometry to measure circulating histones against sepsis progression

Using mass spectrometry to measure circulating histones against sepsis progression

BiomedicineMedicine

By Carlos Romá-Mateo

Interior of a human blood vessel. Something looks wrong, very wrong. Bacteria have entered the circulation, and the immunological system is reacting. All the alarms are on fire, while an army of white blood cells comes by, getting ready to unleash hell on the invaders. Suddenly, among these security agents, a neutrophil stands out. It […]

Plasticity in the macrophage activation states

Plasticity in the macrophage activation states

BiomedicineMolecular biology

By Invited Researcher

The immune system is composed of a considerable variety of cell types with different functions. One of the most important cells involved in the innate immunity are the macrophages. These cells have a wide spectrum of functions: from bacteria-killing function to wound healing properties. Classically the macrophages according to their functions have been classified in […]