The identification of previously unknown proteins is a difficult task and often requires to follow unconventional thinking. In my previous post, I have described how the TRPV1 ion channel (formerly known as the capsaicin receptor) was discovered by combining the construction of a cDNA library from primary afferent neurons (DRG neurons) and the functional selection […]
Doing research in molecular biology is not straightforward, because most of the experimental work is based in the study of molecules which cannot be seen by the unaided eye. Instead, we rely on indirect evidence given by methods which are specific for each area of research. Let’s focus here as an illustrative example at someone […]
Laboratory mice are one of the most valuable tools scientists rely on to understand how pathologies work. In order to find a cure for a disease, we need to have comprehensive knowledge of the physiological processes which are impaired. For instance, we can manipulate mice genetically to assess the effect of either the deletion, overexpression […]
We perceive the world surrounding us through our senses. Thanks to them we can have a pleasant time listening to Claude Debussy or get delighted by the scent of rosemary. We blindly trust them, but are they always truthful? A good answer would be they are accurate most of the time, although it seems nature […]
Although it may sound illogical, destruction of cells is as essential as their creation in the course of proper formation, growth and development of multi-cellular organisms. For this reason, cells program deliberately their suicide through a very controlled process, named apoptosis (from the Greek, “fall off”). Our research group at the University of Tübingen, Germany […]
Unveiling the three-dimensional structure of proteins is one of the most useful strategies for understanding the molecular and cellular basis of human pathologies. Since proteins accomplish myriad cellular functions, but they are formed by combinations of only 20 different pieces, the way those pieces are coordinated is critical, and the tiniest difference can change forever […]
I still remember the order and control exhibited by the chemistry of life that they explained to me in the early years of college. For me, the regulation of gene expression was the supreme paradigm of organization. The promoters, those regulatory sequences preceding genes, were unmistakable ports where plenty of proteins (transcription factors and polymerases) […]
We got it wrong. Media have outlined a rosy picture of Oxytocin as the “love hormone” that floods our brain when we interact with toddlers, puppies and beloved ones. However, scientific evidence portrays a dark side of Oxytocin, which better matches the ambivalences of human nature. In addition, Oxytocin has a long time ignored sibling […]
If there should be one rule that could apply to all fields of biological knowledge, it could be that they get more and more complex as we deepen into their study. Regarding genetics, the landscape has become not only more complex but also much more dynamic than initially thought. The old-fashioned concept of genes as […]
Life is sustained by chemical reactions, and the countless reactions that take place in the cells of living organisms that are responsible for every biological process are known as energetic metabolism. Among the others, the brain stands as the most energy-consuming organ, accounting for up to 20 % of the body’s total haul while representing […]