Category archives: Neurobiology

Increased density of synapses in autism spectrum disorders

Increased density of synapses in autism spectrum disorders

NeurobiologyNeuroscience

By José Ramón Alonso

At a synapse, the plasma membrane of the neuron transmitting the information (the presynaptic neuron) is in close proximity to the membrane of the target cell (postsynaptic) and the two are separated by a space known as the synaptic cleft. Both the presynaptic and postsynaptic sites contain extensive assemblies of molecular machinery that link the […]

Mutations in the non-coding genome contribute to autism

Mutations in the non-coding genome contribute to autism

GeneticsNeurobiology

By José Ramón Alonso

A significant portion of an organism’s genome is non-coding; that is, it does not carry information to make proteins. Part of the non-coding DNA is transcribed into functional non-coding RNA molecules (e.g., transfer RNA, ribosomal RNA and regulatory RNA). Other functions of non-coding DNA include transcriptional and translational regulation of protein coding sequences, nuclear scaffold […]

Hungry for hugs

Hungry for hugs

Neurobiology

By José Ramón Alonso

COVID-19 worsens the already existing social difficulties for older adults and the disabled involved in long-term care services and supports; i.e., nursing homes, skilled nursing facilities, and home and community-based services . A hug is a form of non-verbal communication. It can indicate familiarity, love, affection, friendship, brotherhood, or sympathy. We use it when we […]

‘Male’ vs ‘female’ brains: having a mix of both is common and offers big advantages

‘Male’ vs ‘female’ brains: having a mix of both is common and offers big advantages

Neurobiology

By Invited Researcher

From advertising to the workplace, it is often assumed that men and women are fundamentally different – from Mars and Venus, respectively. Of course, we all know people who are more androgynous, having a mix of personality traits that are stereotypically considered to be male or female. Importantly, such “psychological androgyny” has long been associated […]

Is the intranasal route a “backdoor” used by SARS-CoV-2 to reach the brain fortress?

Is the intranasal route a “backdoor” used by SARS-CoV-2 to reach the brain fortress?

BiomedicineNeurobiology

By Invited Researcher

The intranasal route is a rapid, efficient and direct way for different biological agents, small molecules, drugs and chemical compounds to reach the brain. It seems amazing, but people that snort a line of coke already knew that… To date, its mechanism of diffusion is believed to be using either olfactory nerve tracts or dense […]

Transcranial direct current stimulation and depression

Transcranial direct current stimulation and depression

NeurobiologyNeuroscience

By José Ramón Alonso

Depression is a psychiatric and psychological diagnosis that describes a temporary or permanent mood disorder characterized by feelings of dejection, unhappiness and guilt. Depressed people show a low mood and an aversion to activity and are characterized by sadness, difficulty thinking and concentrating, and a significant increase or decrease in appetite and time spent sleeping […]

Coronavirus in the brain

Coronavirus in the brain

Neurobiology

By José Ramón Alonso

To date, more than 50 million people have been infected with the new coronavirus, SARS-CoV-2, and more than 1,2 million have died. It is a global problem, affecting everyone, but we are still learning how it infects, how it behaves, what causes harm to humans. The virus is spread by the droplets produced by an […]