Category archives: Pharmacy

Antibody-drug conjugates, a fine example of teamwork

Antibody-drug conjugates, a fine example of teamwork

BiomedicineMolecular biologyPharmacy

By Isabel Perez Castro

The immune system is a complex network that recognises foreign substances in the body. When it detects an alien substance (antigen), it creates antibodies to attack and destroy it. This system protects vertebrates against viruses, bacteria, fungi and other parasites, and is the reason for the “rejection” after organ transplants. When we have cancer, our […]

Novel strategies to selectively reduce pain

Novel strategies to selectively reduce pain

MedicineNeurobiologyPharmacy

By Sergio Laínez

A recurrent problem with pain is the absence of therapeutic strategies to selectively block the nociceptors (neurons responsible to detect painful stimuli) that need to be targeted for a particular indication. Things get even worse if we take into account that some molecules used for pain management do affect other, more general physiological processes. Local […]

Riboflavin as a bioorthogonal photocatalyst

Riboflavin as a bioorthogonal photocatalyst

ChemistryCondensed matterDIPC BiochemistryDIPC PhotochemistryPharmacy

By DIPC

The combination of catalysis and bioorthogonality promises have an impact on drug discovery and bioimaging. Bioorthogonality, a term coined by Carolyn R. Bertozzi in 2003, refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes. Hence, catalytic turnover can boost the efficiency of bioorthogonal chemical reactions, unveiling […]

Combatting antimicrobial resistance with a ruthenium-based photorelease antimicrobial therapy

Combatting antimicrobial resistance with a ruthenium-based photorelease antimicrobial therapy

ChemistryCondensed matterMedicineMicrobiologyPharmacy

By DIPC

Antimicrobial resistance is a complex problem that contributes to health and economic losses worldwide. Resistance to antimicrobial therapies reduces the effectiveness of current drugs, leading to increased morbidity, mortality, and health care expenditure. Because globalization increases the vulnerability of any country to diseases occurring in other countries, resistance presents a major threat to global public […]

How drug discovery works: finding new strategies against Kaposi’s sarcoma

How drug discovery works: finding new strategies against Kaposi’s sarcoma

BiomedicineMedicinePharmacy

By Isabel Perez Castro

15% of human cancers worldwide may be attributed to viruses,1 with both DNA and RNA viruses being capable of causing the disease. Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA viruses capable of causing the development of human cancer, whereas human T lymphotrophic virus type 1 and […]

Melodrama with happy ending for Duchenne Muscular Dystrophy patients

Melodrama with happy ending for Duchenne Muscular Dystrophy patients

BiologyBiomedicineGeneticsMedicinePharmacy

By Sergio Laínez

Patients suffering from rare diseases (defined by the European as those affecting less than 5 in 10000 people) have traditionally been overlooked by pharmaceutical companies. They are usually looking for the next blockbuster drug, so the lack of a large patient pool means they may not generate the revenue needed to justify the R&D financial […]