Interior of a human blood vessel. Something looks wrong, very wrong. Bacteria have entered the circulation, and the immunological system is reacting. All the alarms are on fire, while an army of white blood cells comes by, getting ready to unleash hell on the invaders. Suddenly, among these security agents, a neutrophil stands out. It […]
If there should be one rule that could apply to all fields of biological knowledge, it could be that they get more and more complex as we deepen into their study. Regarding genetics, the landscape has become not only more complex but also much more dynamic than initially thought. The old-fashioned concept of genes as […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Replicative senescence is a process […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently, he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Cell migration is key to […]
This article is not about supporting the use of animals for research or to justify the need of such models for the advance of our society (many others have addressed that already). This post is neither about the constant pressure that researchers feel from peers, funding bodies or institutions to do more and more. The […]
Almost every one of our body cells bears in its nucleus about 2 meters of DNA containing the genes that shape our being. All that, roughly 20.000 protein-coding genes, regulatory and unknown-function sequences, tightly packed inside a structure that has a volume of only a few cubic micrometres. How this huge amount of material is […]
Aging is one of those topics mankind is always trying to understand, especially whether it can be reversed or stopped. With increasing age come not only alterations in appearance, but also associated changes like the degeneration of tissues such as muscles, bone and neural tissues or a higher predisposition for disease. In recent years, we […]
Around 80% of the single nucleotide polymorphisms (SNPs) associated to many human diseases map to non-coding regions. Long non-coding RNAs (lncRNAs) represent a large portion of non-coding regions across the genome, however the link between the disease-associated SNPs on lncRNA expression or function, and the implications for disease, remain uncharacterized. Celiac disease is complex immune […]
In multicellular organisms, embryonic stem cells develop into any of the different cell types that will form the adult, and along the development, they silence or activate different parts of the genome, giving rise to distinct cell identities, which are maintained throughout adult life by epigenetic mechanisms. A similar procedure may be at work at […]
I still remember the order and control exhibited by the chemistry of life that they explained to me in the early years of college. For me, the regulation of gene expression was the supreme paradigm of organization. The promoters, those regulatory sequences preceding genes, were unmistakable ports where plenty of proteins (transcription factors and polymerases) […]