Search results: histone

Using mass spectrometry to measure circulating histones against sepsis progression

Using mass spectrometry to measure circulating histones against sepsis progression

BiomedicineMedicine

By Carlos Romá-Mateo

Interior of a human blood vessel. Something looks wrong, very wrong. Bacteria have entered the circulation, and the immunological system is reacting. All the alarms are on fire, while an army of white blood cells comes by, getting ready to unleash hell on the invaders. Suddenly, among these security agents, a neutrophil stands out. It […]

One year or one cell division older?

One year or one cell division older?

BiologyBiomedicineHealthMolecular biology

By Invited Researcher

Aging is one of those topics mankind is always trying to understand, especially whether it can be reversed or stopped. With increasing age come not only alterations in appearance, but also associated changes like the degeneration of tissues such as muscles, bone and neural tissues or a higher predisposition for disease. In recent years, we […]

SNPs, RNA and Celiac Disease

SNPs, RNA and Celiac Disease

BiochemistryBiomedicineGeneticsHealth

By Invited Researcher

Around 80% of the single nucleotide polymorphisms (SNPs) associated to many human diseases map to non-coding regions. Long non-coding RNAs (lncRNAs) represent a large portion of non-coding regions across the genome, however the link between the disease-associated SNPs on lncRNA expression or function, and the implications for disease, remain uncharacterized. Celiac disease is complex immune […]

Changing the way of life

Changing the way of life

Biology

By José Ramón Alonso

In multicellular organisms, embryonic stem cells develop into any of the different cell types that will form the adult, and along the development, they silence or activate different parts of the genome, giving rise to distinct cell identities, which are maintained throughout adult life by epigenetic mechanisms. A similar procedure may be at work at […]

Transcriptional noise seems to correlate with more closed chromatin environments.

Transcriptional noise seems to correlate with more closed chromatin environments.

GeneticsMolecular biology

By Daniel Moreno Andrés

I still remember the order and control exhibited by the chemistry of life that they explained to me in the early years of college. For me, the regulation of gene expression was the supreme paradigm of organization. The promoters, those regulatory sequences preceding genes, were unmistakable ports where plenty of proteins (transcription factors and polymerases) […]

MI weekly selection #147

MI weekly selection #147

Humanities & Social SciencesScienceTechnologyWeekly Selection

By César Tomé

A predicted collision between pair of black holes The prediction late last year of a collision between a pair of supermassive black holes in a galaxy about 3.5 billion light-years from Earth has gotten support from a new study by scientists at Columbia University. Last year, scientists noticed a flickering pulse from the galaxy’s quasar […]

Epigenetics of ant size

Epigenetics of ant size

BiologyGenetics

By José Ramón Alonso

The term epigenetics refers to heritable changes in gene expression (active vs. inactive genes) that does not involve changes to the underlying DNA sequence. It results in change in phenotype without a change in genotype. An easily comprehensible example are identical twins: since they develop from a single fertilized egg, they have the same genome […]