Search results: histone

Using mass spectrometry to measure circulating histones against sepsis progression

Using mass spectrometry to measure circulating histones against sepsis progression

BiomedicineMedicine

By Carlos Romá-Mateo

Interior of a human blood vessel. Something looks wrong, very wrong. Bacteria have entered the circulation, and the immunological system is reacting. All the alarms are on fire, while an army of white blood cells comes by, getting ready to unleash hell on the invaders. Suddenly, among these security agents, a neutrophil stands out. It […]

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

Biomedicine

By Invited Researcher

Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal expansion of plasma cells in the bone marrow (BM) . Nearly 90% of myeloma patients suffer from skeletal-related events during the course of the disease that not only affect the quality of life but also their overall survival . Myeloma-associated bone disease (MBD) is […]

AINU, a powerful AI tool for studying cell heterogeneity

AINU, a powerful AI tool for studying cell heterogeneity

BiologyComputer scienceDIPC SupercomputingGenetics

By DIPC

Chromatin is a complex of DNA and histone, a protein, in the nucleus of a cell. One of the main functions of chromatin is to help DNA packing. Cellular phenotypic heterogeneity is a key determinant of many biological functions; yet, it is still not clear whether it stems from the modifications of the chromatin structure […]

Repurposing ponatinib for ALT-specific minority types of recurrent tumors

Repurposing ponatinib for ALT-specific minority types of recurrent tumors

BiomedicinePharmacy

By Invited Researcher

Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Replicative senescence is a process […]

One year or one cell division older?

One year or one cell division older?

BiologyBiomedicineHealthMolecular biology

By Invited Researcher

Aging is one of those topics mankind is always trying to understand, especially whether it can be reversed or stopped. With increasing age come not only alterations in appearance, but also associated changes like the degeneration of tissues such as muscles, bone and neural tissues or a higher predisposition for disease. In recent years, we […]

SNPs, RNA and Celiac Disease

SNPs, RNA and Celiac Disease

BiochemistryBiomedicineGeneticsHealth

By Invited Researcher

Around 80% of the single nucleotide polymorphisms (SNPs) associated to many human diseases map to non-coding regions. Long non-coding RNAs (lncRNAs) represent a large portion of non-coding regions across the genome, however the link between the disease-associated SNPs on lncRNA expression or function, and the implications for disease, remain uncharacterized. Celiac disease is complex immune […]