Maternal and paternal stress have been proved to be critical aspects of off-spring brain development. High levels of stress on pregnant mothers can alter both placental and embryonic gene expression patterns, misprogramming the brain of the newborn towards psychiatric disorders such as anxiety or depression. At the same level, paternal stress alters microRNAs and other […]
Uropathogenic Escherichia coli (UPEC) is responsible for approximately 90% of urinary tract infections (UTI) seen in individuals with an ordinary anatomy. In ascending infections, fecal bacteria colonize the urethra and spread up the urinary tract to the bladder as well as to the kidneys (causing pyelonephritis), o or the prostate in males. Because women have […]
Little children with autism have more lead and less zinc and manganese than children of the same age without autism. The study has been published in the journal Nature Communications and has been carried out by a team from the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health (NIH) […]
Author: Iker Badiola is an assistant professor in the Department of Cell Biology and Histology, Faculty of Medicine and Nursery, University of Basque Country (UPV/EHU). Colorectal cancer is the third most frequently occurring cancer and a common cause of cancer-related death worldwide. The origin of colorectal cancer is usually a malignant polyp developed in the […]
The haploid human genome contains approximately 3,000,000,000 base pairs of DNA packaged into 23 chromosomes. Most cells in the body, except for eggs and sperm, are diploid, with 23 pairs of chromosomes. That makes a total of 6,000,000,000 base pairs of DNA per cell that, if they were to be put in a straight line […]
Biomedicine • Chemistry • Condensed matter • DIPC Photochemistry
Metal complexes are typically regarded as catalysts that convert organic substrates into more valuable compounds; however, to date, catalytic transformations of metal complexes are practically unknown and represent a complete new way of thinking in catalysis. Their development can expand the scope of bioorthogonal chemical reactions to inorganic substances and metal-based prodrugs, fostering the creation […]
Estrogens are steroid hormones affecting several organs including mammary glands. More precisely, these glands exert their action by means of estrogens through the e strogen receptor (ER), a transcription factor belonging to the family of nuclear receptors. So far, two types of ERs have been identified: alpha and beta. ER-beta is expressed in all mammary […]
During the Cold War the competition between both sides, Russia and the United States of America, caused a quick development of military and spacial technology: while the Soviet Union was the first country responsible for an orbital launch (Sputnik 1), the first nation to ever send a man to space and pioneered spacewalks, the U […]
Like the river of Heraclitus, our bones are constantly changing. Although it may look tough and immutable , the bone is a very dynamic tissue that is constantly formed and destroyed, having different appearances during each of the stages of life. Bone destruction or reabsorption is mediated by a particular cellular type known as the […]
The mineralocorticoid receptor (MR) is an atypical nuclear receptor. In principle, it may seem a mere receptor with a specific ligand and an evident role: it is capable of detecting mineralocorticoids (like aldosterone), exerting an essential function controlling sodium and water reabsorption in the kidneys. In fact, knockout mice lacking MR die shortly after being […]