In 1928, Santiago Ramón y Cajal, the founder of modern neuroscience, wrote that the brains of adult humans never make new neurons. “Once development was ended,” he proclaimed, “the founts of growth and regeneration … dried up irrevocably. In the adult centers the nerve paths are something fixed, ended and immutable. Everything must die, nothing […]
The Mütter Museum in Philadelphia is one of those must go places for any brain enthusiast. The collection beautifully represents the history of modern medicine, including a repository of skulls used in phrenological studies, broken cranial bones à la Phineas Gage, diseased coronal cuts, American civil war surgical memorabilia, and a great little gem: a […]
Contrary to what was thought some years ago, the adult central nervous system is capable of generating new neurons, some of which are integrated into functional circuits and seem to be essential for processes such as memory and learning. The question of why these new neurons are not capable of replacing those lost in neurodegenerative […]
When we hear somebody wheezing, coughing, showing chest tightness and shortness of breath, most of us will immediately recognize the underlying cause: Asthma . This is not a minor issue, but one affecting approximately 5% of the entire world population (and steeply growing every year) and causing the death of nearly 400000 people back in […]
Microglial cells are the immune cells that reside in the central nervous system. They have phagocytic capacity, constitute 10% of the cells of the brain and form a fairly regular three-dimensional network in which each microglia has a unique territory. Its cell body presents many expansions with numerous fine processes, amazingly mobile, with which they […]
A placebo is a substance or treatment that does not contain any active ingredient or rest in a physiological procedure out of the placebo effect, but still achieves a real change. The placebo effect is a psychobiological phenomenon, but it generates authentic physical changes, something that can be observed, for example, in the heartbeat, blood […]
Thomas C. Südhof (Göttingen, Germany, December 22, 1955) is a neurobiologist awarded in 2013 with the Nobel Prize in Medicine for his studies on the trafficking of vesicles in the cell. Südhof has just published an article in the journal Cell, one of the best in the world, about neurexins, one of the most interesting […]
A recurrent problem with pain is the absence of therapeutic strategies to selectively block the nociceptors (neurons responsible to detect painful stimuli) that need to be targeted for a particular indication. Things get even worse if we take into account that some molecules used for pain management do affect other, more general physiological processes. Local […]
The question of how human interaction works is a neurochemical one, but it’s not easy to solve. While many experiments cannot be performed on humans or primates, smaller laboratory animals are useless for this research due to their differences with us. But prairie voles (Microtus ochrogaster) have social traits that had previously been assumed as […]
The number of genes linked to autism has not stopped growing in the last decade. Although there are hundreds of variants that are more frequent in people who are diagnosed with autism spectrum disorders (ASD) than in the general population, there are sixty genes that have a clearer linkage and could help build the genetic […]