Antidepressants are the mainstay for treating depression, but their use is clouded by doubts about their short-, medium- and long-term efficacy. This is not to say that we should not use them, as these drugs save lives in many cases, but a recent review reinforces these questions as it sees little difference in the quality […]
Catalysis-based approaches for the activation of anticancer rely on the use of metal catalysts capable of deprotecting inactive precursors of organic drugs or transforming key biomolecules available in the cellular environment. Nevertheless, the efficiency of most of the schemes described so far is rather low, limiting the benefits of catalytic amplification as a strategy for […]
Computer science • Genetics • Health • Medicine • Molecular biology • Pharmacy
A number of technologies and tools got a chance to prove themselves for the first time in the context of COVID-19. Three researchers working in gene-based vaccines, wearable diagnostics and drug discovery explain how their work rose to the challenge of the pandemic, and their hopes that each technology is now poised to continue making […]
Auranofin is a gold (Au) salt classified by the World Health Organization as an antirheumatic agent. It was approved for the treatment of rheumatoid arthritis in 1985, but is no longer a first-line treatment due to its adverse effects on a long-term basis. But the drug is important in another way. The discovery that auranofin […]
Wouldn´t it be great to have a drug that could kill specifically our old damaged cells allowing us to have a better health at an advanced age? But we are not talking about a dreamed magic immortality pill. Senolytic drugs, compounds that kill senescent cells, are already a reality and represent a new concept that […]
Health • Medicine • Neuroscience • Pharmacy
Ayahuasca is an illegal entheogenic drug, substances that have the capacity to generate a mystical experience, a psychological sensation of contact with the divinity. Ayahuasca is an infusion prepared from the Banisteriopsis caapi liana and other ingredients, which include leaves of Psychotria viridis , Diplopyterys cabrerana and Mimosa tenuiflora . Psychotria has dimethyltryptamine (DMT), a […]
I n the age of bacteria resistant to multiple antibiotics, the so-called superbacteria, it is critical to our future the development of novel therapeutic strategies. Lytic enzymes encoded by bacteriophages – viruses that specifically kill bacteria, also called lysins or enzybiotics, are effective agents for preventing and controlling diseases caused by Gram+ bacteria, including Streptococcus […]
Author: Leyre Urigüen is a researcher at the Department of Pharmacology, University of the Basque Country UPV/EHU and Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM Cannabis, also called marijuana, is a drug that comes from the plant Cannabis sativa (hemp plant). The plant contains more than 400 different chemicals, of which approximately […]
Lipinski’s “rule of five”, 1 very well known by medicinal chemists, has been defined as a set of rules, based on the number 5 -hence its name-, to evaluate the “drug-likeness” of a given molecule. The rules are: – The molecule should have no more than 5 H-bond donors and 10 H-bond acceptors (i.e. N […]
Our society will be facing a number of health-related challenges in the near future, partly as a consequence of our own practices. Perhaps the best known examples are the (severe) health issues linked to smoking (not just to smokers, but also their children via epigenetic changes) or the abnormally high intake of carbohydrates, with the […]