Dip. Di Chemica, Università di Torino, via P. Giuria 7, 10125, Torino, Italy * adrian.matencioduran@unito.it The last articles of one of us (Matencio) [1,2,3,4] were about the different uses of a complexing agent called cyclodextrin (CD), a torus-shaped oligosaccharide made up of α-(1,4) linked glucose units, the most common CDs being α, β and γ-CD […]
On our unique planet, life evolved under the pressure of natural selection. The evolution theory of Darwin demonstrates the incredible plasticity of the living organism. For millions of years, living organisms explored the conformational universe of proteins introducing new structures and function through genetic mutations. The genetic modifications are translated into the sequence of amino-acids […]
Departamento de Bioquímica y Biología molecular-A, Facultad de Biología, Universidad de Murcia, E-30100 Murcia, Spain * adrian.matencio@um.es Antimicrobial resistance is a problem in our society. Although several authors have focused on seeking new molecules with antimicrobial activity, resistance has increased. Several authors are looking for new antimicrobial substances or seeking to improve the use of […]
Molecular recognition is a critical process for many biological functions and consists in non-covalent binding of different molecules, such as protein-protein, antigen-antibody and many others. The host-guest molecules involved often show a shape complementarity, and one of the leading specification for molecular recognition is that the interaction must be selective, i.e. the host should strongly […]
It is time to round off this trilogy of articles about the importance of basic science nowadays. But first, how does science improve? A research team selects a topic, creates its hypothesis and workflow and, perhaps, tries to publish an article with the findings. This article is read by a new research team, who will […]
Author: Francisco J. Blanco is an Ikerbasque Research Professor at CIC bioGUNE Molecular interactions in cell membranes, particularly lipid-protein interactions in their hydrophobic core, are difficult to analyse and remain poorly characterised despite high relevance in physiological and pathological processes. Structural rearrangements in membranes and embedded proteins, and the way molecular interactions contribute to their […]
“ It is often said that all the conditions for the first production of a living organism are now present, which could ever have been present.— But if (& oh what a big if) we could conceive in some warm little pond with all sorts of ammonia & phosphoric salts, light, heat, electricity etc present […]
Uropathogenic Escherichia coli (UPEC) is responsible for approximately 90% of urinary tract infections (UTI) seen in individuals with an ordinary anatomy. In ascending infections, fecal bacteria colonize the urethra and spread up the urinary tract to the bladder as well as to the kidneys (causing pyelonephritis), o or the prostate in males. Because women have […]
From nucleic acids to proteins and sugar chains, all life is made up of polymers, large molecules made up of sequences of small units called monomers. However, how these macromolecules first appeared on the surface of Earth is still controversial. It is generally assumed that, right before life started, our planet was covered in very […]
Applicability or some usefulness is the mantra of new I+D research. However, in trying to obtain results or confirm an application we often forget to check or study the conditions and methods used. One example could be the different methodologies that we can be used to define antioxidant capacity. An antioxidant is a molecule that […]