Category archives: Biology

A membrane with voltage-dependent conductances increases the energy efficiency of fly photoreceptors

A membrane with voltage-dependent conductances increases the energy efficiency of fly photoreceptors

BiologyNeurobiology

By Francisco J Hernández

The neuronal membrane, like membranes surrounding other cells, is mainly formed by a lipid surface impermeable to ions. It is only through ion channels, small protein pores embedded in the membrane, that ions can cross, allowing electrical current to charge or discharge the neuron. The inclusion of ion channels in a membrane, determines its electrical […]

Melodrama with happy ending for Duchenne Muscular Dystrophy patients

Melodrama with happy ending for Duchenne Muscular Dystrophy patients

BiologyBiomedicineGeneticsMedicinePharmacy

By Sergio Laínez

Patients suffering from rare diseases (defined by the European as those affecting less than 5 in 10000 people) have traditionally been overlooked by pharmaceutical companies. They are usually looking for the next blockbuster drug, so the lack of a large patient pool means they may not generate the revenue needed to justify the R&D financial […]

Mediterranean diet and brain shrinkage

Mediterranean diet and brain shrinkage

BiologyHealthNeurobiology

By José Ramón Alonso

The Mediterranean diet is a modern nutritional reference originally inspired by the dietary patterns of Greece, Southern Italy, and Spain in the 1940s and 1950s. The main components of this diet include proportionally high consumption of olive oil, legumes, unrefined cereals, fruits, and vegetables, moderate to high consumption of fish, moderate consumption of dairy products […]

Molecular Detectives: discovering new ion channels (II)

Molecular Detectives: discovering new ion channels (II)

BiologyBiomedicineGeneticsMolecular biology

By Sergio Laínez

The identification of previously unknown proteins is a difficult task and often requires to follow unconventional thinking. In my previous post, I have described how the TRPV1 ion channel (formerly known as the capsaicin receptor) was discovered by combining the construction of a cDNA library from primary afferent neurons (DRG neurons) and the functional selection […]

Molecular Detectives: discovering new ion channels (I)

Molecular Detectives: discovering new ion channels (I)

BiologyBiomedicineGeneticsMolecular biology

By Sergio Laínez

Doing research in molecular biology is not straightforward, because most of the experimental work is based in the study of molecules which cannot be seen by the unaided eye. Instead, we rely on indirect evidence given by methods which are specific for each area of research. Let’s focus here as an illustrative example at someone […]

Change your flavor

Change your flavor

BiologyHealthNeurobiology

By José Ramón Alonso

Flavor is a brain construction: we have olfactory and taste receptors and our central nervous system combines both types of information in what we call flavor. Malaria is an infectious disease affecting humans and other animals caused by parasitic protozoans belonging to the Plasmodium genre. It is transmitted by the bite of the female Anopheles […]