Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the uncontrolled expansion of the immature myeloid cells . The 5-year survival rates of young patients are 40–50% and less than 15% for patients aged over 60 . For this reason, a great effort has been made to decipher the molecular events underlying AML […]
Acute myeloid leukemia (AML) is a stem cell disease caused by the massive mobilization and differentiation arrest in primordial granulocytes. AML is characterized by a low survival rate and high recurrence . Although differentiation-induction therapy represents an innovative treatment strategy for AML , many problems still exist, including irreversible resistance, toxic effects, and limitations of […]
Acute Myeloid Leukemia (AML) is a hematopoietic neoplasm characterized by the proliferation and accumulation of aberrant immature myeloid progenitor cells. AML is associated with poor clinical outcome and high mortality, with an overall five-year survival rate of less than 15-30%. For AML patients, standard therapies often fail to achieve the complete remission, disease relapse is […]
Acute myeloid leukemia (AML) is the most common acute leukemia in adults and a common pediatric cancer. Most often, AML develops from cells that would turn into white blood cells. AML is divided into different subtypes based on the cell type and maturation stage. Currently, monocytic AML, including acute myelomonocytic leukemia (M4) and acute monocytic […]
Acute B-cell progenitor acute lymphoblastic leukemia (B-ALL) is a clonal hematopoietic neoplasm characterized by the proliferation and accumulation of B-lymphoid progenitor cells throughout the bone marrow. Although important studies have characterized the underlying biological pathways that underpin therapy failure , resistance and subsequent relapse remain a leading cause of cancer-related deaths . One approach to […]
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. This cancer is characterized by the rapid growth of immature myeloid precursors that occupy and alter the bone marrow (BM) niche where normal hematopoietic stems cells (HSCs) reside (the “niche” is the in vivo microenvironment where stem cells reside and receive […]
Acute leukemia is characterized by the proliferation and accumulation of hematopoietic progenitor cells (which are able to differentiate to create specialized cell types) in the bone marrow that impede normal blood production. D epending on the cell population affected, it can be classified in Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML). ALL starts […]
Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Research in oncology advances very […]
The immune system is a complex network that recognises foreign substances in the body. When it detects an alien substance (antigen), it creates antibodies to attack and destroy it. This system protects vertebrates against viruses, bacteria, fungi and other parasites, and is the reason for the “rejection” after organ transplants. When we have cancer, our […]
Humanities & Social Sciences • Science • Technology • Weekly Selection
19 elements to have atomic weights adjusted Aluminum, cadmium, gold and arsenic are among 19 elements that are having their atomic weights adjusted by the International Union of Pure and Applied Chemistry. More precise measurements are now available leading to the new weight calculations, which happens rarely. The atomic weight of nonmetal selenium hasn’t been […]