Search results: Acute myeloid leukemia

TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice

TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice

Biomedicine

By Invited Researcher

Acute myeloid leukemia (AML) is a stem cell disease caused by the massive mobilization and differentiation arrest in primordial granulocytes. AML is characterized by a low survival rate and high recurrence . Although differentiation-induction therapy represents an innovative treatment strategy for AML , many problems still exist, including irreversible resistance, toxic effects, and limitations of […]

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

Biomedicine

By Invited Researcher

Acute Myeloid Leukemia (AML) is a hematopoietic neoplasm characterized by the proliferation and accumulation of aberrant immature myeloid progenitor cells. AML is associated with poor clinical outcome and high mortality, with an overall five-year survival rate of less than 15-30%. For AML patients, standard therapies often fail to achieve the complete remission, disease relapse is […]

Antibody-drug conjugates for the treatment of acute myeloid leukemia

Antibody-drug conjugates for the treatment of acute myeloid leukemia

Biomedicine

By Invited Researcher

Acute myeloid leukemia (AML) is the most common acute leukemia in adults and a common pediatric cancer. Most often, AML develops from cells that would turn into white blood cells. AML is divided into different subtypes based on the cell type and maturation stage. Currently, monocytic AML, including acute myelomonocytic leukemia (M4) and acute monocytic […]

TRAF6 functions as a tumor suppressor in myeloid malignancies

TRAF6 functions as a tumor suppressor in myeloid malignancies

Biomedicine

By Invited Researcher

Hematopoietic stem cells (HSC) accumulate somatic mutations during ageing in healthy individuals . Despite most of these mutations are inconsequential, some HSC can acquire specific mutations providing a competitive advantage leading to a process known as “clonal hematopoiesis of indeterminant potential” (CHIP) . The most common CHIP mutations affects to DNMT3A and TET2 genes and […]

Remodeling of the immune microenvironment in B-ALL leukemia

Remodeling of the immune microenvironment in B-ALL leukemia

Biomedicine

By Invited Researcher

Acute B-cell progenitor acute lymphoblastic leukemia (B-ALL) is a clonal hematopoietic neoplasm characterized by the proliferation and accumulation of B-lymphoid progenitor cells throughout the bone marrow. Although important studies have characterized the underlying biological pathways that underpin therapy failure , resistance and subsequent relapse remain a leading cause of cancer-related deaths . One approach to […]

Immune-based therapies to fight leukemia

Immune-based therapies to fight leukemia

BiomedicineMedicine

By Invited Researcher

Acute leukemia is characterized by the proliferation and accumulation of hematopoietic progenitor cells (which are able to differentiate to create specialized cell types) in the bone marrow that impede normal blood production. D epending on the cell population affected, it can be classified in Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML). ALL starts […]

Dr. Jekyll and Mr. Hyde: what changes in a stem cell to become malignant?

Dr. Jekyll and Mr. Hyde: what changes in a stem cell to become malignant?

Biomedicine

By Invited Researcher

Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. Research in oncology advances very […]

Antibody-drug conjugates, a fine example of teamwork

Antibody-drug conjugates, a fine example of teamwork

BiomedicineMolecular biologyPharmacy

By Isabel Perez Castro

The immune system is a complex network that recognises foreign substances in the body. When it detects an alien substance (antigen), it creates antibodies to attack and destroy it. This system protects vertebrates against viruses, bacteria, fungi and other parasites, and is the reason for the “rejection” after organ transplants. When we have cancer, our […]