The stem cell research field shocked the scientific community back in 2006 thanks to Shinya Yamanaka, who found a way to obtain pluripotent stem cells from adult somatic cells . The recipe consisted of just four genes encoding for transcription factors allowing him to reprogram mouse fibroblasts into induced pluripotent stem cells (iPSCs). The “Yamanaka […]
Around 80% of the single nucleotide polymorphisms (SNPs) associated to many human diseases map to non-coding regions. Long non-coding RNAs (lncRNAs) represent a large portion of non-coding regions across the genome, however the link between the disease-associated SNPs on lncRNA expression or function, and the implications for disease, remain uncharacterized. Celiac disease is complex immune […]
Biology • Biomedicine • Health • Medicine
What are lysosomes doing inside your cells? When I was in High School my teacher used to say that lysosomes are only the trash bin of the cell. 20 years later we have discovered a dozen new functions that make this small organelle a core component of the cell. You may already know that the […]
Although it may sound illogical, destruction of cells is as essential as their creation in the course of proper formation, growth and development of multi-cellular organisms. For this reason, cells program deliberately their suicide through a very controlled process, named apoptosis (from the Greek, “fall off”). Our research group at the University of Tübingen, Germany […]
One of the worst things that can happen to someone that loves talking as much as I do is losing my voice. What to most people is just a temporary inconvenience -or a relief depending on who you ask- for some is a real hindrance. Patients that suffer from a permanent impairment to their ability […]
It all began in 1891, when Dr. William B. Coley, a bone sarcoma surgeon at the Memorial Hospital in New York, injected streptococcal organisms into a patient with inoperable cancer. He thought that the infection he induced would have the side effect of shrinking the malignant tumor… and quite surprisingly he was right! The patient’s […]
The scientific community, in their different fields and specialties, has made tremendous progress regarding human health and how we deal with all the maladies affecting mankind. Particularly in cancer, the Pulitzer Prize-winning book entitled “The Emperor of All Maladies” summarizes in a marvelous way this notion. However, I am convinced that our struggle against cancer […]
Increasing numbers of people are developing diabetes in our society and current predictions estimate that nowadays this disease affects about 9% of the whole population. As a consequence, health care systems in industrialized countries have developed many types of clinical interventions that prevent and treat classic complications of this disease and improve the lifetime and […]
The lymphatic system performs important immune functions, and runs parallel to the blood circulatory system to provide a secondary circulation that transports excess interstitial fluid, proteins and metabolic waste products from the systemic tissues back into the blood. For centuries, it was thought that the central nervous system lacks a lymphatic drainage system and the […]
Just as people constantly exchange messages via email, cells communicate with each other and their microenvironment by sending and receiving packages of information; and as we react in one way or another depending on the news we get, cells respond to the “message” by changing the expression of their genes. Following the analogy, in a […]