Category archives: Molecular biology

The skin I live in: the mineralocorticoid receptor

The skin I live in: the mineralocorticoid receptor

BiomedicineMolecular biology

By NuRCaMein

The mineralocorticoid receptor (MR) is an atypical nuclear receptor. In principle, it may seem a mere receptor with a specific ligand and an evident role: it is capable of detecting mineralocorticoids (like aldosterone), exerting an essential function controlling sodium and water reabsorption in the kidneys. In fact, knockout mice lacking MR die shortly after being […]

Marginal macrophages and LXR: living on the edge

Marginal macrophages and LXR: living on the edge

BiomedicineMolecular biology

By NuRCaMein

Our immune system comprises a great variety of cell types and each of these groups is specialized in separate and defined actions. Macrophages play an essential role within this defence system by enhancing the immune response. In particular, they are in charge of “swallowing” (technically speaking, fagocyting) waste products, foreign materials and microorganisms. In addition […]

Antibody-drug conjugates, a fine example of teamwork

Antibody-drug conjugates, a fine example of teamwork

BiomedicineMolecular biologyPharmacy

By Isabel Perez Castro

The immune system is a complex network that recognises foreign substances in the body. When it detects an alien substance (antigen), it creates antibodies to attack and destroy it. This system protects vertebrates against viruses, bacteria, fungi and other parasites, and is the reason for the “rejection” after organ transplants. When we have cancer, our […]