Aging is one of those topics mankind is always trying to understand, especially whether it can be reversed or stopped. With increasing age come not only alterations in appearance, but also associated changes like the degeneration of tissues such as muscles, bone and neural tissues or a higher predisposition for disease. In recent years, we […]
Over the last years, we have found out more and more about the vast amount of bacteria that live with and in us. These populations have been shown to play an important role in our health and are associated with diseases ranging from metabolic disorders such as obesity to autoimmune diseases or cancer. But do […]
Cell signalling is the mechanism by which cells communicate with each other and with their environment. Stimuli, which are generally chemical, are transmitted via a signalling cascade to effector molecules that orchestrate the appropriate response. Signalling pathways are not isolated but they rather form a complex network of biochemical reactions that regulate processes such as […]
There is a word everybody fears and that is because when you listen to it out loud, it could be too late. Even though we have likely coexisted with cancer since complex multicellular organisms evolved, to us human beings, it just seems the number of cases keeps growing every year. Sadly, that seems to be […]
15% of human cancers worldwide may be attributed to viruses, 1 with both DNA and RNA viruses being capable of causing the disease. Epstein-Barr virus, human papilloma virus, hepatitis B virus, and human herpes virus-8 are the four DNA viruses capable of causing the development of human cancer, whereas human T lymphotrophic virus type 1 […]
Biology • Biomedicine • Genetics • Medicine • Pharmacy
Patients suffering from rare diseases (defined by the European as those affecting less than 5 in 10000 people) have traditionally been overlooked by pharmaceutical companies. They are usually looking for the next blockbuster drug, so the lack of a large patient pool means they may not generate the revenue needed to justify the R&D financial […]
Amputees are people that have had a limb removed by trauma, medical illness, or surgery. In this latter case, it is used to control pain or a disease process in the affected limb, such as malignancy or gangrene. Nevertheless, most new amputations occur due to complications of the vascular system, especially from diabetes. It is […]
So many times, I order my coffee while hesitantly eyeing the seductive pastries. This time I’ll resist these sweet beauties. Last night I came across a lecture from Einstein’s friend, Otto Heinrich Warburg (Nobel Prize in Medicine, 1931). It was 1966 and he was at the meeting of Nobel Laureates in Lindau, Germany: “ Cancer […]
The identification of previously unknown proteins is a difficult task and often requires to follow unconventional thinking. In my previous post, I have described how the TRPV1 ion channel (formerly known as the capsaicin receptor) was discovered by combining the construction of a cDNA library from primary afferent neurons (DRG neurons) and the functional selection […]
Doing research in molecular biology is not straightforward, because most of the experimental work is based in the study of molecules which cannot be seen by the unaided eye. Instead, we rely on indirect evidence given by methods which are specific for each area of research. Let’s focus here as an illustrative example at someone […]