T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy that affects both children and adults. Although with current chemotherapy regimens cure is achieved in ~80% of pediatric patients, adults fare more poorly with only 40% 5-year overall survival . Restricted cellular subsets with asymmetrically enriched leukemia-initiating cell (LIC) activity have been reported in human and […]
Biology • Biomedicine • Medicine • Pharmacy
One of the biggest health threats in our current society is not related to a virus, not even to diabetes or cardiovascular disease, but to antimicrobial resistance. In fact, over 5 million deaths per year are associated with resistant bacteria, of which nearly 1.3 million deaths per year are directly attributable to antimicrobial resistance. This […]
Phagocytosis Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Phagocytosis of cancer cells by tumor-associated macrophages (TAMs), which are abundant in the tumor microenvironment (TME), plays a critical role in cancer immunosurveillance . Cancer cells can evade macrophage-mediated phagocytosis (the process by which a cell uses its plasma membrane to engulf particles or […]
Cell division, or mitosis, is a breathtaking choreography that showcases the grandeur of life. The primary objective of this process is to meticulously separate the two copies of the cell genome, presented in the form of chromatin, and allocate them between two daughter cells. Consequently, it holds paramount significance for the reproduction of unicellular organisms […]
Platelets Author: José R. Pineda got his Ph.D. from University of Barcelona in 2006. Since 2007 he has worked for Institut Curie and The French Alternative Energies and Atomic Energy Commission. Currently he is a researcher of the UPV/EHU. He investigates the role of stem cells in physiologic and pathologic conditions. There is currently a […]
Author: Ramón Muñoz-Chápuli has been Professor of Animal Biology in the University of Málaga until his retirement. He has investigated for forty years in the fields of developmental biology and animal evolution. All the cells in our body require a supply of oxygen, although in some cases, they can temporarily rely on anaerobic metabolism. Under […]
Cutaneous Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Cutaneous T-cell lymphoma (CTCL) is a rare type of cancer that begins in white blood cells called T cells (T lymphocytes). These cells normally help the body’s immune system to fight germs and pathogens. In cutaneous T-cell lymphoma, T cells acquire aberrant functions that […]
Hypoxia Author: Marta Irigoyen is a postdoctoral researcher at CIC bioGUNE Despite the fact that c ancer treatments have greatly improved during recent years, chemoresistance remains a major problem in eradicating cancer cells. Drug resistance involves not only many cell intrinsic mechanisms but also extrinsic induced chemoprotection by the tumor microenvironment . In fact, this […]
The recent COVID-19 pandemic has demonstrated the vulnerabilities of our society to infectious diseases and the limitations of the tools available for viruses detection. Polymerase chain reaction (PCR) and antigens tests have been useful to monitor and contain the extension of the last pandemic, however it demonstrated to have severe limitations. PCR is a highly […]
One of the biggest challenges of medical imaging technologies is actually resolving the structures of interest, be it a tumour, a lung or a blood vessel, without the “noise” from other bodily parts like skin or muscle. A new imaging technique allows for visualisation inside intact animals at higher resolution than ever before. A team […]