Category archives: Neurobiology

It’s all your parents’ fault (II): how Darth Vader programmed Luke to have depression

It’s all your parents’ fault (II): how Darth Vader programmed Luke to have depression

GeneticsNeurobiology

By Raúl Delgado-Morales

“ Fear is the path to the dark side. Fear leads to anger. Anger leads to hate. Hate leads to suffering”. Grand Master Yoda This is the second chapter of a series of 2 articles that pretends to illustrate how the emotional state of our parents influence our brain development. The first article focused completely […]

Classification of sensory neuron types applying single-Cell RNA sequencing

Classification of sensory neuron types applying single-Cell RNA sequencing

BiochemistryGeneticsNeurobiology

By Sergio Laínez

In 1968, the Canadian psychologist from McGill University Ronald Melzack described pain as being multidimensional and complex, with sensory-discriminative, affective-motivational and cognitive-evaluative components . Such definition may be a hint as to why the biological meaning of pain has been an (to date) unceasing matter of debate since Aristotle, who thought pain is just a […]

Young blood and old brain rejuvenation

Young blood and old brain rejuvenation

Neurobiology

By Jaime de Juan Sanz

We all have heard stories about young blood-consuming vampires remaining eternally youthful. Although lots of literary fictions have become true with scientific progress, no one would ever believe that young blood could have rejuvenative effects on the elderly. Surprisingly, this is recently becoming true with the increasing evidence in biomedical research showing that old mice […]

Alzheimer’s disease: 3D culture system brings hope to drug discovery

Alzheimer’s disease: 3D culture system brings hope to drug discovery

NeurobiologyNeuroscience

By Raúl Delgado-Morales

Alzheimer’s disease (AD) is one of the most devastating human pathologies. AD is the leading cause of age-related dementia and currently afflicts more than 44 million persons worldwide (World Alzheimer Report 2014). It is characterized by a cognitive decline and memory loss and by the appearance of two pathological hallmarks: beta amyloid plaques and cytoskeletal […]

A new type of spontaneous activity in the brain identified

A new type of spontaneous activity in the brain identified

NeurobiologyNeuroscience

By Jorge Mejías

The study of the spontaneous activity in the brain –and its origin– is one of the major puzzles in modern neural science. In many situations, the same neurons which behave smoothly and in an easily predictable way in in vitro experimental conditions, turn into unpredictable units, firing spikes irregularly and even chaotically, when they are […]